chondrosarcoma

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chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.
References in periodicals archive ?
Currently, no evidence exists to support the use of chemotherapy in the treatment of chondrosarcomas, although it is used by some in the treatment of high-grade tumors with a greater risk for metastases and should be considered in those with lymph node metastasis [22,41].
A 58-year-old male with multiple enchondromas experienced malignant degeneration of one into a chondrosarcoma of the distal femur.
Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma. J Surg Oncol 2010;102:838-43.
There are no reports of chondrosarcoma in parrots and few descriptions in other bird species, such as ruffed grouse (Bonasa umbellus) (SIEGFRIED, 1983), great egret (Ardea herodius occidentalis and Ardea alba) (SPALDING & WOODARD, 1992; KUBO et al., 2007), yellow-collared macaw (Ara auricollis) (KENNEDY et al., 1995), chicken (Gallus gallus domesticus) (DITTMER et al., 2012), and pheasant (Phasianus colchicus) (ERDOGAN et al., 2013).
* As the term implies, conventional chondrosarcomas are much more common.
Patients with chest chondrosarcoma can present with a variety of symptoms depending on tumour size and location.
Unlike chondrosarcoma of bone, there are no differentiated cartilage cells with distinct lacunae seen.[sup.10] In our case S-100 immunomarker was negative, which excludes chondroid differentiation.
Chondrosarcoma and the majority of soft-tissue sarcomas are resistant to chemotherapy, limiting effective treatment of metastases.
Non-conventional chondrosarcomas and chondrogenesis.