chondrosarcoma


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Related to chondrosarcoma: osteosarcoma, mesenchymal chondrosarcoma

chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

/chon·dro·sar·co·ma/ (-sar-ko´ma) a malignant tumor derived from cartilage cells or their precursors.
central chondrosarcoma  one within a bone, usually not associated with a mass.

chondrosarcoma

[kon′drōsärkō′mə] pl. chondrosarcomas, chondrosarcomata
Etymology: Gk, chondros + sarx, flesh, oma, tumor
a malignant neoplasm of cartilaginous cells or their precursors that occurs most frequently in long bones, the pelvic girdle, and the scapula. The tumor is a large, smooth, lobulated growth composed of nodules of hyaline cartilage that may show slight to marked calcification. Also called chondroma sarcomatosum. chondrosarcomatous, adj.
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Chondrosarcoma

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chondrosarcoma

malignant neoplasm of cartilage, arising near ends of long bones, talus or calcaneum; presenting in older adults and only rarely in children; characterized by dull pain and swelling, bone matrix calcification, endosteal scalloping, local cortical thinning and expansion and soft-tissue involvement; difficult to diagnose from radiographs (see Table 1)
Table 1: Tumours arising in bone
Bone tumour typeExamples occurring in lower limb/foot
BenignAneurysmal bone cyst
Solitary osteochondroma
Simple/solitary bone cyst
Osteoid osteoma
Giant-cell tumour
Enchondroma
Chondroblastoma
MalignantChondrosarcoma
Ewing's sarcoma
Osteogenic sarcoma

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.

chondrosarcoma (kon´drōsärkō´mə),

n a malignant neoplasm composed of cartilage-like tissue.
n a malignant cartilage tumor primarily found in younger adults, usually located in or near the jaw.

chondrosarcoma

a malignant tumor derived from cartilage cells or their precursors.
References in periodicals archive ?
One patient mortality was noted in their study with metastases of a chondrosarcoma located in the humerus.
OUMS-27 human chondrosarcoma cells were kindly provided by Dr.
We report 4 new cases of chondrosarcoma of the temporal bone that were treated at our institution over a 20-year period, including 2 cases that were centered on the jugular foramen.
Histological examination (Fig 2) showed the mass to be a chondrosarcoma (grade 1).
Researchers have seen similar results using 2-methoxyestradiol in many other kinds of cancer, including osteosarcoma, leukemia, and chondrosarcoma, a type of cancer affecting the cartilage.
Malignant change in a previously benign tumour is largely restricted to conditions such as multiple exostoses (diaphyseal aclasis) and multiple enchondromatosis or Ollier's disease, where a relatively slow-growing chondrosarcoma develops in middle age.
Of the 38 patients for excision of primary malignancy, the most common tumours were osteosarcoma (5), Ewing's sarcoma (5) and chondrosarcoma (12).
He told her she had a cancerous Cranial Chondrosarcoma and it was embracing so many nerve endings that it was causing numbness, loss of hearing, taste and smell.
Caption: Brian John Monaghan, former president of International Holographic Paper (IHP), Chalfont, PA, died July 20 from chondrosarcoma and leiomyosarcoma.
For Avila, lack of health coverage led to a critically late diagnosis of chondrosarcoma.
Xylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycan.
The ability of a combined therapy with aldoxorubicin and doxorubicin to demonstrate efficacy in this cancer at doses that were well-tolerated indicates its potential for the treatment of other chemotherapeutic-resistant tumors such as chondrosarcoma and chordomas.