chondrosarcoma


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Related to chondrosarcoma: osteosarcoma, mesenchymal chondrosarcoma

chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.
References in periodicals archive ?
In the same month incisional biopsy was done which reported the right foot lesion features that of chondrosarcoma and a section of the bone was also occupied by the tumour.
Mesenchymal chondrosarcoma: a cytogenetic, immunohistochemical and ultrastructural study.
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. J Mol Diagn 2014;16:314-323.
Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study.
Surgical excision has been the initial treatment of choice as chondrosarcoma is traditionally regarded a radio-resistant tumor.
Rushing, "Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and [beta]-catenin, Sox9, and osteocalcin immunostaining of 22 cases," Human Pathology, vol.
Sim, "Secondary chondrosarcoma in osteochondroma: report of 107 patients," Clinical Orthopaedics and Related Research, vol.
It was determined to show biphasic pattern with densely cellular regions of small anaplastic cells and other areas of chondroid differentiation, consistent with diagnosis of mesenchymal chondrosarcoma (Figures 2-4).
Case 2 is a 54-year-old male patient with chondrosarcoma of the proximal humeral bone.
Chondrosarcoma, in Fascicle 2: Tumors of the Bones and Joints.
Chondrosarcoma, a malignant bone tumour constitutes about 9% of primary bone malignancies.