MSCs are beneficial for OA repair techniques due to their anti-inflammatory and chondroprotective
effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages," Journal of Inflammation, vol.
IL-10, which has a chondroprotective
effect, is elevated in the cartilage and synovium of patients with osteoarthritis and acts as a stimulator of chondrocyte proliferation .
Concomitantly, the expression of genes that degrade ECM was diminished and thus reflected a chondroprotective
effect of RHP on cartilage tissue.
In mice, some results may be related to mechanisms regarding the chondroprotective
effect of GEJ achieved through upregulation of bcl-2 mRNA expression and downregulation of caspase-3mRNA expression [18, 30].
effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice.
With up to 40 million Americans suffering from arthritis, 16 million of whom have been diagnosed with osteoarthritis, Olaf Weitz, head of business development--Supplements Group, Martin Bauer Inc., Secaucus, NJ, said the need for anti-inflammatory supplements as well as chondroprotective
supplements to stimulate the production of cartilage tissue is growing.
Chondroitin sulphate could also work as an antiinflammatory and chondroprotective
agent by acting on the cartilage structure.
In vitro studies have shown that glucosamine stimulates the production and repair of proteoglycans, a process that might also occur in vivo, rendering the supplement chondroprotective
Blattes et al., "Anti-inflammatory and chondroprotective
effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis," Arthritis & Rheumatism, vol.
The nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR[gamma]), has been shown to exert an anti-inflammatory and chondroprotective
action, and the modulation of its expression by interleukin 1[beta], or the cartilage-specific disruption of its gene in mice, has been linked to the development of OA [43, 44].
supplements have been a boon to pet owners seeking safe, efficacious products that help maintain healthy connective tissue, support joint function and improve pets' quality of life.