On the other hand, chondroprotective
agents such as the antioxidants have been found to promote cartilage repair by stimulating anabolic metabolism of chondrocytes and/or inhibiting catabolic processes found in OA (Altman et al.
Pharmacological treatment is based on analgesics, anti-inflammatories, and chondroprotective
drugs to relieve pain and improve function.
14] In other words, Mg serves as a chondroprotective
element by increasing the cell proliferation, protein expression, and growth factor efficacy.
effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1 induced NF-B-mediated inflammation and apoptosis.
Anti-inflammatory and chondroprotective
activity of (+)-alpha-pinene: structural and enantiomeric selectivity.
NEM also demonstrated improvements in joint pain and function in a yet to be published canine study, as well as displayed a profound chondroprotective
Veterinarian-prescribed Cosequin and Dasuquin, both FDA-approved, are more expensive, as is Adequan, a chondroprotective
drug injected systemically once or twice a week.
The study sample did not include patients who had one of the following diagnoses: rheumatoid arthritis, ankylopoetic spondylitis, psoriatic arthritis or reactive arthropathy, as well as those patients who used any chondroprotective
drugs, such as corticosteroids, sulfate polysaccharides, chemically modified tetracyclines, diacetylrhein or glucosamine , or who had a history of trauma of the knee in which the prosthesis was implanted, and the patients with general systemic weakness or acute contagious disease.
Hip dysplasia can be managed through balanced nutrition, exercise, chondroprotective
supplements and salvage surgery by performing pectineal myectomy, pelvic osteotomy, intertrochantric osteotomy, excision arthroplasty and total hip prosthesis (Raghuvir et al, 2013, Rawson et al, 2005, Vezzoni et al, 2010, Wallace, 1992).
Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective
effect under oxidative stress.
5 Mrad group showed similar chondroprotective
effects to the 0 Mrad group.
Concentration of chondroprotective
anabolic cytokines is high in PRP compared to whole blood.