Platelet rich plasma (PRP) induces chondroprotection
via increasing autophagy, anti-inflammatory markers, and decrea-sing apoptosis in human osteoarthritic cartilage.
Liu-Bryan, "Peroxisome proliferator-activated receptor y coactivator 1a and FoxO3A mediate chondroprotection
by AMP-activated protein kinase," Arthritis & Rheumatology, vol.
Hilal et al., "Platelet rich plasma (PRP) induces chondroprotection
via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage," Experimental Cell Research, vol.
Sun, "Nutraceuticals: potential for chondroprotection
and molecular targeting of osteoarthritis," International Journal of Molecular Sciences, vol.
Meniscus transplantation using treated xenogeneic meniscal tissue: Viability and chondroprotection
study in rabbits.
In vivo chondroprotection
and metabolic synergy of glucosamine and chondroitin sulfate.
Taken all together, we hypothesize that andrographolide may also relieve joint inflammation and exert chondroprotection
against cytokines induction via several intracellular signaling including NF-kB and MAPK pathways.
Chondroitin is also a naturally occurring glycoaminoglycan that seems to support the efforts of glucosamine as well as provides chondroprotection
while serving as a 'water magnet' within the joint matrix.
Afterward, the injection of an intraarticular suspension of autologous MSCs was seen to evoke a meniscal repair response that resulted in clinical improvement with evidence of chondroprotection
. The cells that were implanted were not identified at the cartilage, but at the surface of the regenerated meniscus.
[sup] injected MSCs encapsulated in self-assembled peptide hydrogels into the rat articular cavity in an OA model and reported evidence of chondroprotection
, as well as of decreased expression of biochemical markers of inflammation and apoptosis.