It was hypothesized that the erroneous differentiation of TDSCs to chondrocytes or osteoblasts leads to chondrometaplasia
and ossification in tendinopathy .
In addition, the bursa may contain chondral or fibrin bodies, and chondrometaplasia can occur within the synovial lining, leading to secondary synovial chondromatosis [4,14,17-20].
Smith, "Bursa formation and synovial chondrometaplasia associated with osteochondromas," American Journal of Clinical Pathology, vol.
Histologic examination reveals foci of chondrometaplasia
in the synovium formed by disorganized cartilage with cytologic atypia, and a differential diagnosis with synovial chondrosarcoma should be performed.
The principal clinical differential diagnosis are extraskeletal mesenchimal chondrosarcoma, giant cell tumor of the tendon sheath with foci of cartilaginous metaplasia, calcifying aponeurotic fibroma, synovial chondromatosis, and nodular chondrometaplasia
. After excision, benign extraskeletal chondroma can recur in 15% to 20% of the cases.
The differential diagnosis of laryngeal chondrosarcoma includes, in addition to chondroma, benign lesions such as chondrometaplasia
and tracheopathia osteoplastica, as well as malignant tumors such as adenocarcinoma and squamous cell carcinoma.
 True chondromas are probably rare; the differential diagnosis includes chondrometaplasia
and low-grade chondrosarcoma.