chondroitinase

chondroitinase

(1) N-Acetylgalactosamine-6-sulfatase, EC 3.1.6.4 (N-Acetyl-d-galactosamine-6-sulfate 6-sulfohydrolase). 
(2) N-Acetylgalactosamine-4-sulfatase, EC 3.1.6.12 (N-Acetyl-d-galactosamine-4-sulfate 4-sulfohydrolase). 
(3) Hyaluronoglucosaminidase, EC 3.2.1.35 (hyaluronate 4-glycanohydrolase).
(4) Chondroitin ABC lyase,  EC 4.2.2.4. 
(5) Chondroitin AC lyase, EC 4.2.2.5.
References in periodicals archive ?
Chondroitinase ABC (ChABC) decomposes chondroitin sulfate proteoglycans in the glial scar that forms following SCI, allowing stem cells to penetrate through the scar and promote recovery of nerve function.
Thus, dermatan sulfate was removed from isolated GAGs samples using depolymerisation with chondroitinase B (from Flavobacterium heparinum); then, the mixture of heparinase I and heparinase III (both from Flavobacterium heparinum) was added to a reaction medium in order to remove heparin sulfate/heparin.
CSPS degradation with chondroitinase ABC enhances axonal sprouting following SCI [27, 28] and stroke [29, 30].
Rather than measuring chondroitin content indirectly by observing how it reacted with another chemical, this method measured it directly by using an enzyme called chondroitinase ACII to break it into smaller pieces that could then be individually measured using chromatography with UV detection.
The majority of developmental work performed in pharmacologic vitreolysis and vitreodynamics involves enzymes including hyaluronidase, chondroitinase, tissue plasminogen activator, dispase, urokinase and plasmin.
The extract is treated for 2 h with chondroitinase B followed by addition of disaccharide internal standard, boiling, and centrifugation.
Building on a technique developed by her colleagues at Case Western Reserve University in Cleveland, Warren injected an enzyme called chondroitinase ABC into the rats' spinal cords to clear out scar tissue a year and a half after the injury.
Chondroitinase ABC promotes functional recovery after spinal cord injury.
Past research suggested one way to promote the growth of injured spinal nerve cells was to administer an enzyme known as chondroitinase ABC (ChABC), which digests scar-forming proteins.
AMSBIO's highly purified Chondroitinase ABC enzyme is supplied protease-free, carrier-free and with low-endotoxin levels for use in neuroscience and regenerative medicine research.
Chondroitinase, an enzyme that encourages nerve plasticity in spinal cord injury, is in preclinical development.