VAR2CSA is a large protein (350 kDa) that is structurally composed of six Duffy binding-like (DBL) domains (DBL1X, DBL2X, DBL3X, DBL4[epsilon], DBL5[epsilon], and DBL6[epsilon]) among them, three mediate binding to chondroitin sulfate A (CSA) (Clausen et al.
Plasmodium falciparum-infected red blood cells (IRBCs) bound to chondroitin sulfate A (CSA) (Figure 6) but not to other extracellular matrix proteins or to other known IRBC receptors.
falciparum erythrocyte membrane protein 1 (PfEMP1) domains (variant protein named VAR2CSA) and chondroitin sulfate A (CSA) on the syncytiotrophoblasts (Figure 6) of placenta (Andersen et al.
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
This type of chondroitin sulfate is sometimes referred to as chondroitin sulfate A or poly-galactosaminoglucuronoglycan sulfate.
Supplements are usually isomeric mixtures of chondroitin sulfate A and chondroitin sulfate C.
In degenerative joint disease, such as osteoarthritis, there is a loss of chondroitin sulfate as the cartilage erodes.