Biosynthesis of the chondroitin sulfate
The study also showed that patients who were being treated with NSAIDs in addition to chondroitin sulfate
showed a significant reduction in synovial membrane thickness (1.3 plus or minus 0.3 mm in 6 months vs.
OMERACT-OARSI responses also were not significantly different from placebo, with the rate of responses to glucosamine, chondroitin sulfate
, and combination being 3.7, 6.6, and 8.7 percentage points higher than placebo, respectively.
The multi-center, randomized, double-blind, controlled and comparative study analyzed chondroitin sulfate
and celecoxib over the course of three years.
A Study results released in 2006 showed that glucosamine and chondroitin sulfate
supplements gave significant relief to patients with moderate-to-severe OA pain; however, it was not effective in relieving pain in patients with mild OA.
Cem Gabay and colleagues from the University of Geneva School of Medicine (Switzerland) enrolled 162 subjects, mean age 83 years, with severely symptomatic OA, assigning each to receive either 6 months of daily chondroitin (800 mg; as purified chondroitin sulfate
derived from fish sources) or placebo.
This investigation was undertaken to evaluate the therapeutic efficacy and safety of glycosylated undenatured type II collagen (UC-II) alone or in combination with glucosamine HCl and chondroitin sulfate
in arthritic dogs.
slows the progression of knee osteoarthritis, according to findings from a pilot study that used magnetic resonance imaging to assess joint structural changes.
11 November 2010 - US Watson Pharmaceuticals Inc (NYSE: WPI) said on Wednesday that the US pilot study evaluating Uracyst (sodium chondroitin sulfate
solution 2.0%) for the treatment of interstitial cystitis did not meet predefined efficacy endpoints.
The dietary supplements glucosamine and chondroitin sulfate
failed to show overall efficacy for pain relief in osteoarthritis of the knee in a large double-blind trial, but questions concerning their potential benefits in patients with more severe pain remain, as do suggestions that longer term use may have disease-modifying effects.
SAN DIEGO -- Glucosamine and chondroitin sulfate
may be an effective combination in reducing pain associated with osteoarthritis of the knee, researchers at the recent American College of Rheumatology Annual Scientific Meeting here reported.
In a randomized trial, 32 patients with knee osteoarthritis (OA) applied as needed the topical cream containing glucosamine sulfate 30 mg/g, chondroitin sulfate
50 mg/g, shark cartilage 140 mg/g, camphor, and peppermint oil.