Yang et al., "Composite poly(l-lactic-acid)/silk fibroin scaffold prepared by electrospinning promotes chondrogenesis
for cartilage tissue engineering," Journal of Biomaterials Applications, vol.
The TGF-[beta] superfamily of proteins and their members such as BMP, fibroblast growth factors, and IGF are well-established regulatory factors in chondrogenesis
In Vitro Chondrogenesis
. Previously isolated, characterized, and cryobanked passage 3 SFMSCs and BMMSCs were first evaluated by in vitro chondrogenic differentiation.
(2005).The adaptive remodeling of condylar cartilage--a transition from chondrogenesis
Aetiology of the skeletal dysmorphology syndrome campomelic dysplasia: expression of the SOX9 gene during chondrogenesis
in mouse embryos.
qRT-PCR assay of MSCs showed a potent increase in the mRNA expression levels of chondrogenesis
markers including Sox6, COL2A1, COMP, AGC1, COL9A2 and COL1A1 in response to overexpressing PDK2 (P<0.01 or P<0.05, Figure 3).
Spector, "Modulation of mesenchymal stem cell chondrogenesis
in a tunable hyaluronic acid hydrogel microenvironment," Biomaterials, vol.
Of note, SOX5 has also been demonstrated to play an important role during chondrogenesis
, but there were no skeletal deformities or morphological stigmata compatible with cartilage defects in the SOX5 disease subjects described here.
Current treatment modalities to improve osteogenesis, chondrogenesis
, and tenogenesis include conventional injections of many growth factors in a protein/peptide structure, such as BMP-2, BMP-12, and/or platelet-rich plasma [9-11].
Uyeda et al., "Regulation of growth plate chondrogenesis
by bone morphogenetic protein2," Endocrinology, vol.
Despite this, a high cell density is critical for maximising chondrogenesis
 and remains a pertinent issue in cartilage regeneration.
WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis
and craniofacial development.