chondrocytes


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chondrocytes

Cells that secrete the non-cellular matrix of cartilage and become trapped in minute spaces within it.
References in periodicals archive ?
In the proliferative zone (ZP), the chondrocytes adopt a flattened appearance, begin to divide, are organized in columns and initiate the synthesis of substantial amounts of extracellular matrix of collagen (MEC) (van der Eerden et al.
It is also in accordance with the previous studies on rats which showed that the iron excess affects the height of growth plate mainly by affecting the size of chondrocytes and amount of matrix.
The effects of these inflammatory mediators in articular cartilage, chondrocytes and synoviocytes have been reported.
One goal of the study was to determine how crosslinking and pH variations affect the cell viability of chondrocytes and the mechanics, gelation kinetics and printability of collagen bioinks.
Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.
MMP-9 (gelatinase B), similar to MMP-1, is most active during embryonic development, being essential to angiogenesis in the growth plate and apoptosis of hypertrophic chondrocytes in utero [16].
Since 1994 it has been shown that autologous chondrocytes may generate highest tissue quality, also superior to concurring techniques with respect to clinical outcome [4, 5].
Some studies have reported that excess apoptosis of chondrocytes and mesenchymal stem cells (MSCs), and the decreased abilities of these cells to replicate and differentiate contribute to OA.
Subsequently a calcified matrix is synthesized by hypertrophic chondrocytes before they undergo apoptosis.
Chondrocytes created from adult stem cells are currently being experimentally used but as they cannot be currently be produced in large amounts the procedure is expensive.
Cartilage is composed of mature chondrocytes surrounded by a matrix: these chondrocytes are usually dormant; however, chondrocytes are active, during fetal life when cartilage matrix is soft [9].
The challenge will be to investigate the expression, function and regulation of plasma membrane ion channels and calcium signalling pathways of OA chondrocytes by using state of the art proteomic and electrophysiological techniques.