However, these current therapeutic options should not cause damage to chondrocytes
, since this could aggravate the conditions of joint disease.
Table: Comparison of mean values of chondrocyte
count between control group A and experimental groups B1, B2 and B3.
Hyaline cartilage, such as that found in the nose, microscopically consists of chondrocytes
. Derived from mesenchymal stem cells (MSCs), chondrocytes
are responsible for producing the extracellular matrix that mainly consists of Type II collagen and proteoglycans.
This procedure was done repeatedly on day 1, 3, 7, 10 and 14 to acquire an impression how the chondrocyte
proliferated or gone through apoptosis over longer observations.
were obtained from 10 OA patients (aged 58-75 years) who had undergone total knee replacement at the Department of Orthopedic Surgery, Huadong Hospital, Fudan University.
Generally, OA is an articular cartilage injury caused by an imbalance in the degradation and synthesis of chondrocytes
, extracellular matrix, and subchondral bone.
Defects were filled with gelMA/gellan using four different spatial chondrocyte
distributions (20 x [10.sup.6]/ml of the defect volume; Fig.
Bartlett et al., "Who is the ideal candidate for autologous chondrocyte
implantation?" The Journal of Bone & Joint Surgery (British Volume), vol.
(c) Fibrous tissue formation was observed instead of chondrocyte
and extracellular matrix (ECM).
They have demonstrated that human urine-derived stem cells (hUSCs) can be differentiated into chondrocytes
in vitro and enhanced wounded rabbit knee joint healing in vivo.
Based on this background, it is proposed as a contraindication to apply therapeutic US in pediatric patients in areas close to the PC, since it could cause a premature closure of the plaque or alterations in the chondrocyte
Increased proteoglycan and cartilage turnover (and decreases in their synthesis), increased chondrocyte
apoptosis and chondrocyte
depletion have been observed as results (34-37).