The presence of chondroblasts
and hyaline matrix with or without focal calcification will differentiate chondroblastoma from benign giant-cell tumours.
Annacontini et al., "Adipose-derived mesenchymal stromal (stem) cells differentiate to osteoblast and chondroblast
lineages upon incubation with conditioned media from dental pulp stem cell-derived osteoblasts and auricle cartilage chondrocytes," Journal of Biological Regulators and Homeostatic Agents, vol.
Local and systemic growth Factors (GF) stimulate the MSCs to migrate to the focus of the fracture and through the osteoinduction, to differentiate into chondroblasts
and osteoblasts and thus, form the bone callus.
In the experimental group, at 4 weeks after of ASC injection, typical cartilaginous features with chondrocytes, chondroblasts
, and cartilage-specific extracellular matrix (ECM) deposition were shown.
MSCs should be able to differentiate into osteoblasts, adipocytes, and chondroblasts
in vitro (21).
Characterization consisted of differentiation in adipocytes, chondroblasts
and osteoblasts, using a protocol already established in the laboratory (9).
Finally, the fourth calcified layer is the deepest and is formed by chondroblasts
, chondrocytes and osteoblasts distributed throughout the articular cartilage.
(3) Chondroblastoma is typically seen in an epiphyseal location and is characterized histologically by the proliferation of immature chondrocytes (chondroblasts
) along with other secondary elements, such as mature cartilage, giant cells, calcification, and occasionally, aneurysmal bone cyst formation.
Mesenchymal stem cells (MSCs) are multipotent stromal cells in connective tissues capable of differentiating into a variety of specialized and functional cells, including osteoblasts, chondroblasts
, myocytes, and adipocytes.
From the histopathological point of view, the findings can be variable and may exist from mature forms with hyaline cartilage arranged in lobes (some with fibrosis, ossification, or myxoid areas) to immature forms with preponderance of chondroblasts
Jin, "MicroRNA-9 regulates survival of chondroblasts
and cartilage integrity by targeting protogenin," Cell Communication and Signaling, vol.
In this process, EV from chondroblasts
and osteoblasts collected inorganic phosphate and calcium from the ECM, followed by mineralization in the lumen to form hydroxyapatite crystals.