cholinesterase inhibitor


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Related to cholinesterase inhibitor: Donepezil, acetylcholine, Memantine

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

cholinesterase inhibitor

an agent or medication with effects that inhibit the enzyme responsible for the reuptake of acetylcholine at cholinergic synapses, thus perpetuating its action at the receptor; most notable therapeutic application is in the treatment of myasthenia gravis or after nondepolarizing neuromuscular relaxants have been administered.

cholinesterase inhibitor

Pharmacology Any agent–eg, pyridostigmine, ambenonium, neostigmine, that inhibits acetylcholinesterase, the enzyme which breaks down acetylcholine, thereby preventing transmission of nerve impulses to a muscle

cho·lin·es·ter·ase in·hib·i·tor

(kō'lin-es'tĕr-ās in-hib'i-tŏr)
A drug, such as neostigmine, which, by inhibiting biodegradation of acetylcholine, restores myoneural function in myasthenia gravis or after nondepolarizing neuromuscular relaxants have been administered.

cholinesterase inhibitor

A drug or agent that blocks the action of CHOLINESTERASE so that acetylcholine accumulates, often dangerously. The insecticides malathion and parathion are cholinesterase inhibitors, as are the drugs physostigmine (eserine), neostigmine, edrophonium, pyridostigmine, tacrine, demecarium and ambendonium. Other cholinesterase inhibitors are the nerve gases sarin, soman and tabun. Sarin has a lethal dose in humans of less than 1 mg.
References in periodicals archive ?
Lindesay, "Cholinesterase inhibitors and cardiovascular disease: a survey of old age psychiatrists' practice," Age and Ageing, vol.
"The data set supporting medical foods is not as robust as the data set supporting cholinesterase inhibitors."
[10] Cholinesterase inhibitors (4.6% of cases), anticoagulant rodenticides and pyrethroids were the most frequent pesticide exposures.
(2001) also showed that CPF is a stronger DNA synthesis inhibitor than CPF-oxon, although it is a weaker cholinesterase inhibitor. Confirming again that certain regions of the developing brain were more susceptible than others, Qiao et al.
Typically combined with a cholinesterase inhibitor. Many clinicians use lower dosages (400 IU b.i.d.
SAN DIEGO -- In a 3-year Swedish study of patients with mild or moderate forms of Alzheimer's disease who were taking cholinesterase inhibitors, varying outcomes were demonstrated in the different domains of the disease and in the scales used.
* Contact your doctor to find out if there is any reason not to begin treatment with memantine and a cholinesterase inhibitor drug, and request the drug combination if deemed appropriate by your doctor.
A few crossover design studies of schizophrenia patients taking antipsychotics included functional magnetic resonance imaging (fMRI) at baseline and after cholinesterase inhibitor and placebo augmentation.
Cholinesterase inhibitors. The findings of some studies suggest that cholinesterase inhibitors may delay the inevitable cognitive decline in AD.
A current hypothesis proposes a compensatory mechanism with functional consequences, whereby cholinesterase activity increases after the poisoning events, which is explained by cholinesterase being quickly synthesized in response to brain hyperexcitability after cholinesterase inhibitor poisoning events and after stress (Meshorer et al.
Rivastigmine, the cholinesterase inhibitor recently approved for mild to moderate Alzheimer's dementia, has a dual mechanism of action that also appears to be effective in later stages of the disease, said Dr.
About two-thirds of the participants consumed 1,000 IU vitamin E twice a day along with a cholinesterase inhibitor drug commonly used to treat their disease.