cholinergic receptors

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Related to cholinergic receptors: Nicotinic receptors

cho·lin·er·gic re·cep·tors

chemical sites in effector cells or at synapses through which acetylcholine exerts its action.

cho·lin·er·gic re·cep·tors

(kō'lin-ĕr'jik rĕ-sep'tŏrz)
Chemical sites in effector cells or at synapses through which acetylcholine exerts its action.


1. parasympathomimetic; activated or transmitted by acetylcholine; said of nerve fibers that liberate acetylcholine at a synapse when a nerve impulse passes, i.e. the parasympathetic fibers.
2. an agent that resembles acetylcholine or simulates its action.

cholinergic blockade
selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions.
cholinergic neurotransmission
that form of neurotransmission which depends on the production of acetylcholine at synapses.
cholinergic receptors
receptor sites on effector organs or at nerve synapses that are stimulated by acetylcholine released by the nerve terminal. There are two types: muscarinic receptors, present primarily on autonomic effector cells, and nicotinic receptors, present primarily on autonomic ganglion cells and on the motor end plates of skeletal muscle.
References in periodicals archive ?
The reduction in presynaptic activity was not compensated by up-regulation of cholinergic receptors, as we found no significant alteration of [m.
In addition to inhibiting cholinesterase, CPF, like nicotine, interacts directly with nicotinic cholinergic receptors (Katz et al.
Chlorpyrifos targets mammalian brain development through a combination of effects directed at cholinergic receptors and intracellular signaling cascades that are involved in cell differentiation.
Indeed, both chlorpyrifos and chlorpyrifos oxon are capable of direct actions on muscarinic and nicotinic cholinergic receptors, influencing second messenger production (26-28) and ion fluxes (29,30); hence, even some of the cholinotypic actions on developing systems may be mechanistically unrelated to inhibition of cholinesterase activity.
Ideally, the system could then be used to identify specific cellular mechanisms for the actions of chlorpyrifos, notably the cholinergic receptors and appropriate signaling cascades, as well as potentially providing a screening mechanism with which to compare chlorpyrifos to other organophosphates or alternative classes of pesticides.
If chlorpyrifos elicits developmental anomalies through effects on cholinergic receptors or signaling cascades linked to the receptors, then antagonists should prevent or augment the effects.
These findings imply a direct interaction of chlorpyrifos with cholinergic receptors and signaling cascades in the developing mammalian CNS, consistent with results obtained from in vitro examinations of potential receptor targets (26,27,29).
The inhibition of these enzymes increases the availability of Ach, which in turn can stimulate cholinergic receptors producing both nicotinic and muscarinic effects in the organism such as muscle contractions and secretions in many glands (5).
Under normal physiologic conditions, the cholinergic receptors are usually operative through Ach action, and atropine is known to occupy the cholinergic receptors and interfere with the action of Ach (5,6).
Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with [sup.