choline acetyltransferase


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Related to choline acetyltransferase: choline acetylase

choline

 [ko´lēn]
an amine that occurs in phosphatidylcholine and acetylcholine, and is an important methyl donor in intermediary metabolism. Choline is a lipotropic agent, a substance that decreases liver fat content by increasing phospholipid turnover. It was formerly considered to be a B vitamin and is now classified as a pseudovitamin, although it is still sometimes classified as part of the vitamin B complex. Vitamin B12 and folacin are involved in the synthesis of choline.
choline acetylase (choline acetyltransferase) an enzyme that brings about the synthesis of acetylcholine.
choline magnesium trisalicylate see under trisalicylate.
choline salicylate see salicylate.

cho·line a·ce·tyl·trans·fer·ase

[MIM*118490]
an enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
Synonym(s): choline acetylase

choline acetyltransferase

An enzyme encoded by CHAT on chromosome 10q11.2 that binds acetylCoA to choline, controlling acetylcholine production at the synapses of autonomic nervous system, muscle and the sympathetic nervous system.

Molecular pathology
Polymorphisms of CHAT have been associated with choline acetyltransferase depletion in Alzheimer’s disease and cognitive impairment. CHAT mutations are associated with congenital myasthenic syndrome with episodic apnoea.

choline acetyltransferase

Choline acetylase An enzyme which controls acetylcholine production in synapses of the autonomic nervous system, muscle, and SNS, which may be depleted in Alzheimer's disease

cho·line a·ce·tyl·trans·fer·ase

(kō'lēn ăs'e-til-trans'fĕr-ās)
An enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
References in periodicals archive ?
Prevention of age-related memory deficit in transgenic mice by human choline acetyltransferase. European Journal of Pharmacology, 683: 174-178.
Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [[sup.3]H]hemicholinium-3 binding.
Previous work has shown that Aroclor 1254 (a mixture of PCB congeners) consumed during pregnancy and lactation resulted in smaller offspring, offspring with depressed circulating levels of [T.sub.3] and [T.sub.4], problems with spatial learning, and alterations in choline acetyltransferase (ChAT) activity.
In cultured basal forebrain neurons, Ninjin-yoei-to has been reported to increase choline acetyltransferase activity (Kiyohara et al.
In cultured basal forebrain neurons, Ninjin-yoei-to has been reported to increase the choline acetyltransferase activity (Kiyohara et al.
It has been reported that Alzheimer disease (AD) and aging are associated with decreased levels of choline acetyltransferase (ChAT: EC2.3.1.6) activity and degeneration of cholinergic neurons in the central nervous system (Davis and Maloney,1976; Whitehouse et al., 1992; Bartus et al., 1982).
Measurements of striatal and hippocampal choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities