cholic acid


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Related to cholic acid: cholesterol

cholic acid

 [ko´lik, kol´ik]
one of the primary bile acids, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion.

cho·lic ac·id

(kō'lik as'id),
A family of steroids comprising the bile acids (or salts), generally in conjugated form (for example, glycocholic and taurocholic acids). Chemically, cholic acids are cholan-24-oic (cholanic) acids (the terminal C24 of cholane becoming a -COOH group); biologically, cholic acids are derived from cholesterol (a cholestane derivative) and display varying degrees of oxidation (OH groups) and orientation at positions 3, 7, and 12. It is these oxidations and orientations that distinguish the several cholic acid; for example, cholic acid is 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid, and deoxycholic acid is 3α,12α-dihydroxy-5β-cholanic acid. Cholic acid is a naturally occurring detergent in mammals that aids in the digestion of fats.

cholic acid

(kō′lĭk)
n.
An abundant crystalline bile acid, C24H40O5, derived from cholesterol.

cho·lic ac·id

(kō'lik as'id)
A family of steroids comprising the bile acids (or salts), generally in conjugated form (e.g., glycocholic and taurocholic acids); cholic acids are derived from cholesterol.

cholic acid

a crystalline BILE acid.
References in periodicals archive ?
Our research group developed 3[beta]-[[sup.18]F]fluorocholic acid (3[beta]-[[sup.18]F]FCA), a cholic acid derivative of which the 3[alpha]-OH function is substituted for a 3[beta]-fluorine atom.
Metal cholates preparation in aqueous solvent: cholic acid was dissolved in aqueous sodium hydroxide solution, then treated with one equivalent of aqueous metal salt solution.
Unless alternative nondestructive methods of hydrolysis are used, GC-MS cannot be reliably used to monitor changes in the urinary excretion of 3[beta]-sulfated-[[DELTA].sup.5]-cholenoic acids in patients undergoing cholic acid therapy, in whom reductions in the concentrations of atypical bile acids represent one of the main biochemical endpoints for efficacy.
Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; G, glycine-conjugated; LCA, lithocholic acid; MCA, muricholic acid; NS, not significant; T, taurine-conjugated species; UDCA, ursodeoxycholic acid.
Cholic acid will be marketed as Cholbam by Asklepion Pharmaceuticals, the FDA said in its statement.
In this research, cholic acid and cheno anti-accumulation agents have been used to prevent the accumulation of dye materials based on indigos.
This extract was used for the estimation of fecal sterols and bile acids (cholic acid and deoxycholic acid) by the methods of Zlatkis et al.
cholic acid and desoxycholic acid) and cholestanes ([C.sub.27]) (e.g.
From day 13 of gestation, rats in Group A and Group B were injected intraperitoneally with bile acid (cholic acid (CA), Sigma-Aldrich, USA) for 8 days consecutively.
The whole series of 11 studied BAs comprises nonsubstituted (CnA), monosubstituted (lithocholic acid, LCA), disubstituted (deoxycholic acid, DCA, and derivatives chenodeoxycholic, ursodeoxycholic, and hyodeoxycholic acids, CDCA, UDCA, and HDCA, resp.), and trisubstituted (cholic acid, CA, and dehydroderivatives, 3DHDCA, DHDCA, 3DHCA, and DHCA) cholanic acids.
In the in vivo experiment, SCID mice were fed a diet containing 2% of either PS mixture or cholesterol plus 0.2% cholic acid and implanted with 2 x 10(6) tumour cells per mouse.
The French pharmaceutical laboratory CTRS confirmed in a statement, published on 18 September, that the European Commission has granted marketing authorisation for Orphacol (cholic acid), an orphan medicinal product for the treatment of two extremely rare and life-threatening liver conditions.