CSA-8, CSA-13, CSA-142 and CSA-192 were synthesized from cholic
acid as previously described (Guan et al.
After 59 days (weight maintenance phase), the rats started to be fed on diets formulated according to the AIN-93M diet, while keeping the same percentages indicated above for the fibers, cholesterol and cholic
In a population of patients with NASH, levels of unconjugated cholic
acid and chenodeoxycholic acid were, respectively, increased.
Two primary bile acids, cholic
acid and chenodeoxycholic acid, are synthesised in the liver, and gut microbiota produces secondary bile acids through two enzymatic reactions .
Soon after our first report of [[sup.18]F]LCATD as the first [18F]fluorine-labelled bile acid , another derivative of cholic
acid, 3[beta]-[18F]fluorocholic acid ([[sup.18]F] FCA) was reported by De Lombaerde et al.
The classic (neutral) biosynthesis pathway, localised exclusively in the liver and accounting for at least 75% of the total BS pool, starts with modification of the sterol ring, followed by side chain cleavage reactions to synthesise cholic
and chenodeoxycholic acid, constituting the primary BS in humans.
Dietary supplementation with the bile acid cholic
acid in mice reverses HFD-induced weight gain by activating D2 and converting T4 to T3 through TGR5 receptor activation.
LDLr-/- mice (n=10/group) were fed with a standard diet (Nuvital, Brazil) as the control group (C), or with a hyperlipidic diet (HL group; 20% total fat, 1.25% cholesterol and 0.5% cholic
acid), with water and food ad libitum.
Villanova et al., "Changes in biliary lipid secretion and cholic
acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects," Italian Journal of Gastroenterology, vol.
Primary bile acids (i.e., cholic
acid and chenodeoxycholic acid) are metabolized into secondary bile acids (i.e., deoxycholic acid and lithocholic acid) by anaerobic bacteria.
The lipid extracts were resuspended in Triton buffer (20 mL of 0.5 M potassium phosphate, pH 7.4, 0.25 M NaCl, 25 mM cholic
acid, 0.5% Triton[R] X-100), and TG levels were determined using an enzymatic-colorimetric method according to the manufacturer's instructions (Chod-Pap; Roche Diagnostic GmbH, Mannheim, Germany).
Moreover, because of its complex components including bilirubin, cholic
acid, bile acids and cholesterol, and so forth, we have established HPLC fingerprints for the effective quality control of CBS .