cholestyramine


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resin

 [rez´in]
1. a solid or semisolid organic substance exuded by plants or by insects feeding on plants, or produced synthetically; they are insoluble in water but mostly soluble in alcohol or ether. adj., adj res´inous.
2. a compound made by condensation or polymerization of low-molecular-weight organic compounds.
acrylic r's products of the polymerization of acrylic or methacrylic acid or their derivatives, used in fabrication of medical prostheses and dental restorations and appliances.
anion exchange resin see ion-exchange resin.
cation exchange resin see ion-exchange resin.
cholestyramine resin a synthetic, strongly basic anion exchange resin in the chloride form which chelates bile salts in the intestine, thus preventing their reabsorption; used as an adjunctive therapy to diet in management of certain hypercholesterolemias and in the symptomatic relief of pruritus associated with bile stasis.
composite resin a synthetic resin, usually acrylic based, to which a high percentage of ceramic reinforcing filler has been added, such as particles of glass or silica coated with a coupling agent to bind them to the matrix; used chiefly in dental restorations. Called also composite.
epoxy resin a tough, chemically resistant, adhesive, flexible, dimensionally stable resin of epoxy polymers; used as denture base material.
ion exchange resin a high-molecular-weight insoluble polymer of simple organic compounds capable of exchanging its attached ions for other ions in the surrounding medium; classified as (a)cation or anion exchange resins, depending on which ions the resin exchanges; and (b) carboxylic, sulfonic, and so on depending on the nature of the active groups.
podophyllum resin a mixture of resins from podophyllum, used as a topical caustic in treatment of laryngeal papillomas, condylomata acuminata, and other epitheliomas.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cholestyramine

LoCHOLEST, LoCHOLEST Light, Novo-Cholamine (CA), Novo-Cholamine Light (CA), Prevalite, Questran, Questran Light

Pharmacologic class: Bile acid sequestrant

Therapeutic class: Lipid-lowering agent

Pregnancy risk category C

Action

Combines with bile acid in GI tract to form insoluble complex excreted in feces. Complex regulates and increases cholesterol synthesis, thereby decreasing serum cholesterol and low-density lipoprotein levels.

Availability

Powder for suspension; powder for suspension with aspartame: 4 g cholestyramine/packet or scoop

Indications and dosages

Primary hypercholesterolemia and pruritus caused by biliary obstruction; primary hyperlipidemia

Adults: Initially, 4 g P.O. once or twice daily. May increase as needed and tolerated, up to 24 g/day in six divided doses.

Off-label uses

• Antibiotic-induced pseudomembranous colitis

• Adjunct in infantile diarrhea

• Digoxin toxicity

Contraindications

• Hypersensitivity to drug, its components, or other bile-acid sequestering resins

• Complete biliary obstruction

• Phenylketonuria (suspension containing aspartame)

Precautions

Use cautiously in:

• history of constipation or abnormal intestinal function

• pregnant patients

• children.

Administration

• Mix powder with soup, cereal, pulpy fruit, juice, milk, or water.

• Administer 1 hour before or 4 to 6 hours after other drugs.

• Be aware that fat-soluble vitamin supplements may be necessary with long-term drug use.

Adverse reactions

CNS: headache, anxiety, vertigo, dizziness, insomnia, fatigue, syncope

EENT: tinnitus

GI: nausea, vomiting, constipation, abdominal discomfort, fecal impaction, flatulence, hemorrhoids, perianal irritation, steatorrhea

GU: hematuria, dysuria, diuresis, burnt odor to urine

Hematologic: anemia, ecchymosis

Hepatic: hepatic dysfunction

Metabolic: vitamin A, D, E, and K deficiencies; hyperchloremic acidosis

Musculoskeletal: joint pain, arthritis, back pain, muscle pain

Respiratory: wheezing, asthma

Skin: hypersensitivity reaction (irritation, rash, urticaria)

Other: tongue irritation

Interactions

Drug-drug. Acetaminophen, amiodarone, clindamycin, clofibrate, corticosteroids, digoxin, diuretics, fat-soluble vitamins (A, D, E, and K), gemfibrozil, glipizide, imipramine, methotrexate, methyldopa, mycophenolate, niacin, nonsteroidal anti-inflammatory drugs, penicillin, phenytoin, phosphates, propranolol, tetracyclines, tolbutamide, thyroid preparations, ursodiol, warfarin: decreased absorption and effects of these drugs

Drug-diagnostic tests. Alkaline phosphatase: increased level

Hemoglobin: decreased value

Prothrombin time: increased

Patient monitoring

• Monitor CBC with white cell differential and liver function test results.

• If bleeding or bruising occurs, monitor prothrombin time. Drug may reduce vitamin K absorption.

• Watch for constipation, especially in patients with coronary artery disease. Take appropriate steps to prevent this problem.

Patient teaching

Instruct patient to immediately report yellowing of skin or eyes or easy bruising or bleeding.

• Tell patient to take drug 1 hour before or 4 to 6 hours after other drugs.

• Teach patient about role of diet in controlling cholesterol level and preventing constipation.

• Instruct patient to avoid inhaling or ingesting raw powder. Tell him to mix powder with food, juice, or milk before consuming.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

cho·le·styr·a·mine res·in

an anion exchange resin used to bind dietary cholesterol and hence prevent its systemic absorption. Used to treat hypercholesteremia. Can bind many acidic drugs in the gastrointestinal tract and prevent their absorption.
Synonym(s): cholestyramine
Farlex Partner Medical Dictionary © Farlex 2012

cholestyramine

(kō′lĭ-stîr′ə-mēn′, kō-lĕs′tə-răm′ēn)
n.
A drug that binds to intestinal bile acids and promotes their excretion, used to lower serum cholesterol levels and to treat itching associated with partial biliary obstruction.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cholestyramine

Cardiology A bile acid sequestrant that ↑ conversion of cholesterol into bile acids, and secondarily stimulates the synthesis of LD receptors Pros ↓ risk of CAD, generally safe Cons Expensive, inconvenient, GI side effects. See Cholesterol.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

cholestyramine

Colestyramine, a drug used in the treatment of HYPERLIPIDAEMIA. It is an anion-exchange resin that binds bile acids so that they cannot be reabsorbed and are lost in the stools. This stimulates the conversion of body cholesterol into more bile acids. A brand name is Questran.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Cholestyramine (Questran)

A drug used to bind with bile acids and prevent their reabsorption and to stimulate fat absorption.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
In an open multicenter study [41] conducted in 98 IBS-D patients who underwent the SeHCAT test, 56 patients showed altered SeHCAT retention and 42 completed a course of cholestyramine therapy at the mean dose of 4.8 g per day: only three did not respond to the drug.
Cholestyramine might be prescribed as an alternative drug when the first-line therapy cannot be used for thyroid storm treatment [3].
Also Known Colesevelam Kayexalte Renagel, As (Welchol), Renvela colestipol (Colestid), and cholestyramine (LoCholest, Prevalite, and Questran) Target ion Bile acids Potassium Phosphate Clinical Diarrhea Chronic Chronic history renal renal failure failure Mucosal No Yes Possible injury Fish-scales None Yes Yes H&# Bright orange Purple 2-toned pink/yellow AFB Dull yellow Black Magenta
Compared to the standard drug cholestyramine, both bark extracts showed significantly high (p < 0.05) sodium taurocholate binding at the studied concentrations of 1, 2, and 3 mg/mL.
Intrahepatic Cholestasis Of Pregnancy, treatment includes Ursodiol or Ursodeoxycholic acid Cholestyramine to bind the bile salt Phenobarbital has also been used the syndrome resolve the softer delivery.
Thus, in a lower-court case in which the plaintiff suffered a perforated bowel purportedly from the use of cholestyramine and codeine that resulted in severe constipation from huge fecaliths, the doctor defendant was able to escape liability because the patient failed to exclude a barium enema procedure as the cause of the perforation.
Other agents such as phenobarbital and the bile acid sequestrant, cholestyramine, have been studied in a small randomised trial in France, with no significant benefit.
Flatulence could be a side-effect so you may want to try cholestyramine instead.
These include antacids that contain aluminum or magnesium (Maalox, Mylanta); some cholesterol-lowering drugs, including cholestyramine (Questran) and colestipol (Colestid); the heartburn drug metoclopramide (Reglan); sulfasalazine (Azulfidine), which is used to treat ulcerative colitis and rheumatoid arthritis; and bulk laxatives (such as psyllium, Metamucil or Citrucel).
In the first group, samples were obtained from 10 individuals (5 men, 5 women) before and during chronic cholestyramine treatment (mentioned in Results).
Cholestyramine can be used to increase the fecal excretion of protoporphyrins in liver dysfunction (1,3,10) (SOR: A).
Cholestyramine decreases T3's clinical effect, as can antacids and iron and calcium supplements.