LIPA

(redirected from cholesterol ester hydrolase)
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Related to cholesterol ester hydrolase: cholesterol esterase, cholesteryl ester hydrolase

LIPA

A gene on chromosome 10q23.2 that encodes lipase A, the lysosomal acid lipase (i.e., cholesterol ester hydrolase) that catalyses the hydrolysis of cholesteryl esters and triglycerides in lysosomes.

Molecular pathology
LIPA mutations are linked to CESD and Wolman disease.
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References in periodicals archive ?
[1] Nonstandard abbreviations: ALBK, Abell-Levy-Brodie-Kendall; CEH, cholesterol ester hydrolase; CO, cholesterol oxidase; POD, peroxidase; CDH, cholesterol dehydrogenase; and DADS, N-ethyl-N-(2-hydroxy-3-sulfopropyl)3,5-dimethoxyaniline.
Cholesterol esters are hydrolyzed to free cholesterol by cholesterol ester hydrolase (EC 3.1.1.13).