(d) 400x, a multinucleated giant cell with a cholesterol cleft
(arrow); an early manifestation in the development of cholesterol granulomas.
Tonsils 1 Reactive Lymphoid Hyperplasia 158 100 2 Surface Ulcerations 62 39.24 3 Bacterial Colonies 58 36.71 4 Salivary Gland Tissues 20 12.66 5 Granulations 16 10.13 6 Abscess 12 7.59 7 Neutrophil Infiltrates 8 5.06 8 Keratin Flakes 6 3.80 9 Mucus Glands 4 2.53 10 Cholesterol Cleft
2 1.27 11 Cyst 2 1.27 12 Cartilage 1 0.63 13 Atrophy 0 0 14 Fibrosis 0 0 CONCLUSION: Considering the absence of neoplasia in any of the one hundred and fifty eight tonsillar specimens and lack of specific differentiating features between adult and paediatric tonsillectomy specimens, it's our recommendation that subjecting a tonsil removed under the indication of chronic tonsillitis for routine histopathological examination is unnecessary and could constitute an economic burden on the patient.
Rupture may result in fibrosis, granulation tissue, hemorrhage, and cholesterol cleft
formation or cholesterol granuloma.
Epithelial lining of odontogenic keratocysts and cholesterol clefts
in the fibrous capsule of radicular cyst are shown in figures 1 and 2 respectively.
The lumen was filled with amorphous, eosinophilic material with cholesterol clefts
. A thin rim of compressed thyroid tissue was noted outside the fibrous wall.
These sections were studied for the presence of fibrosis, giant cells, granulomas, cholesterol clefts
, acute inflammation, and association with adenocarcinomas.
A focal area with cholesterol clefts
was also evident.
Histologically, it is manifested by collection of lipid laden macrophages admixed with mixed inflammatory infiltrate composed of lymphocytes, plasma cells, neutrophils and multinucleated giant cells with or without cholesterol clefts
Histopathology revealed that granulomatous tissue consisted of cholesterol clefts
, lymphoplasmacellular infiltrates, marked hemosiderin deposits, and multinucleated foreign body giant cells around cholesterol clefts
[Figure 1]e-[Figure 1]g.
The lumen contained eosinophilic homogenous hyalinized material with many cholesterol clefts
and red blood cells.
Diagnosis of maxillary sinus CG is based on microscopic analysis of a foreign body reaction characterized by foreign body giant cells and longitudinal cholesterol clefts
, granulocytes, foam cells, and macrophages filled with hemosiderin [2, 3].
and foreign body type giant cell reaction was also noted.