cholestatic jaundice


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jaundice

 [jawn´dis]
yellowness of skin, sclerae, mucous membranes, and excretions due to hyperbilirubinemia and deposition of bile pigments. It is usually first noticeable in the eyes, although it may come on so gradually that it is not immediately noticed by those in daily contact with the jaundiced person. Called also icterus.

Jaundice is not a disease; it is a symptom of a number of different diseases and disorders of the liver and gallbladder and of hemolytic blood disorders. One such disorder is the presence of a gallstone in the common bile duct, which carries bile from the liver to the intestine. This may obstruct the flow of bile, causing it to accumulate and enter the bloodstream. The obstruction of bile flow may cause bile to enter the urine, making it dark in color, and also decrease the bile in the stool, making it light and clay-colored. This condition requires surgery to remove the gallstone before it causes serious liver injury.

The pigment causing jaundice is called bilirubin. It is derived from hemoglobin that is released when erythrocytes are hemolyzed and therefore is constantly being formed and introduced into the blood as worn-out or defective erythrocytes are destroyed by the body. Normally the liver cells absorb the bilirubin and secrete it along with other bile constituents. If the liver is diseased, or if the flow of bile is obstructed, or if destruction of erythrocytes is excessive, the bilirubin accumulates in the blood and eventually will produce jaundice. Determination of the level of bilirubin in the blood is of value in detecting elevated bilirubin levels at the earliest stages before jaundice appears, when liver disease or hemolytic anemia is suspected.
Patient Care. Assessment of the patient with jaundice includes observations of the degree and location of yellowing, noting the color of urine and stools, and the presence of itching. Since jaundice can be accompanied by severe itching, frequent skin care is important to preserve skin integrity. Tepid sponge baths can help reduce discomfort and promote rest.

Patients with severe jaundice are at risk for encephalopathic changes that produce confusion, impaired mentation, and altered levels of consciousness. The potential for injury is increased and demands vigilance and safety measures to protect the patient.
Jaundice may be attributable to prehepatic (A), hepatic (B), or posthepatic (C) causes. From Damjanov, 2000.
acholuric jaundice jaundice without bilirubinemia, associated with elevated unconjugated bilirubin that is not excreted by the kidney. Familial acholuric jaundice is another name for the hereditary form of hemolytic jaundice.
breast milk jaundice elevated unconjugated bilirubin in some breast-fed infants due to the presence of an abnormal pregnane that inhibits glucuronyl transferase conjugating activity.
cholestatic jaundice that resulting from abnormality of bile flow in the liver.
familial nonhemolytic jaundice Gilbert disease.
hematogenous jaundice hemolytic jaundice.
hemolytic jaundice see hemolytic jaundice.
hepatocellular jaundice jaundice caused by injury to or disease of the liver cells.
leptospiral jaundice Weil's syndrome.
neonatal jaundice (jaundice of the newborn) icterus neonatorum.
nonhemolytic jaundice that due to an abnor-mality in bilirubin metabolism.
obstructive jaundice that due to blockage of the flow of bile.
physiologic jaundice mild icterus neonatorum during the first few days after birth.

cho·le·stat·ic jaun·dice

jaundice produced by inspissated bile or bile plugs in small biliary passages in the liver.

cho·le·stat·ic jaun·dice

(kō'lĕ-stat'ik jawn'dis)
Jaundice with bile stasis in inflamed intrahepatic bile ducts; usually due to toxic effects of a drug.
References in periodicals archive ?
Reported cases about bile cast nephropathy due to cholestatic jaundice after using anabolic androgenic steroids include a bodybuilder abusing a regimen of steroids including stanozolol that were successfully treated with plasmapheresis [5] and 2 cases with stanozolol used for 2 months successfully treated with hemodialysis [16, 17].
Ling, "Early diagnosis of neonatal cholestatic jaundice: Test at 2 weeks," Canadian Family Physician, vol.
Definitive exclusion of biliary atresia in infants with cholestatic jaundice: The role of percutaneous cholecystocholangiography.
As aldosterone level was elevated, 21-hydroxylase deficiency was excluded and provisional diagnosis of 11-beta hydroxylase deficiency with cholestatic jaundice was made.
We performed a retrospective review of hospital records of patients with cholestatic jaundice, referred to the Paediatric Surgical Unit of Tygerberg Hospital from 2001 to 2011 (Table 1).
After excluding right ventricular failure, biliary obstruction, superin fection, and hepatocellular carcinoma, the marked cholestatic jaundice was thought to be caused by thyrotoxicosis.
Infants with severe cholestatic jaundice are monitored for purpura and bullous eruptions while receiving phototherapy (AAP, 2004).
Cholestatic jaundice with minimal elevation of transaminase levels has also been reported.
Cases of cholestatic jaundice with minimal elevation of transaminase levels have also been reported.
They include nausea, dizziness, fatigue, shortness of breath, skin rash, nervousness, toxic hepatitis, cholestatic jaundice, nephrotoxicity, and psychosis, particularly with prolonged therapy.
Chlorpromazine is well known to cause cholestatic jaundice and hepatocellular injury.
Amoxicillin is used for bacterial infections like sinusitis, tonsillitis and other conditions, with a list of possible side-effects that include nausea, vomiting, diarrhoea, cholestatic jaundice and anaemia.