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Tending to diminish or stop the flow of bile.
Farlex Partner Medical Dictionary © Farlex 2012


Tending to diminish or stop the flow of bile.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


, cholestasia (ko?le-sta'sis) (ko?le-sta'zh(e-)a) [ chole- + stasis]
Arrest of the flow of bile. This may be due to intrahepatic causes, obstruction of the bile duct by gallstones, or any process that blocks the bile duct (e.g., cancer). cholestatic (ko?le-stat'ik), adjective

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis

obstetric cholestasis

Intrahepatic cholestasis of pregnancy.

progressive familial intrahepatic cholestasis

Byler disease.
Medical Dictionary, © 2009 Farlex and Partners


Tending to diminish or stop the flow of bile.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
We presented a challenging diagnosis of AMS in an adult patient with severe cholestatic hepatitis, requiring a large number of investigations to exclude multiple differential diagnoses.
Severe cholestatic jaundice induced by Epstein-Barr virus infection in the elderly.
One of their patients, originally admitted with acute cholestatic hepatitis and later diagnosed with FMF, was phenotypically similar to our patient in this case report.
Intake of indigenous medication was found to be associated with adverse outcome and it was associated with development of cholestatic hepatitis.
Studies[14] have shown that clozapine can cause acute necrotic hepatitis, cholestatic hepatitis with necrosis of a single hepatocyte, and eosinophil infiltration; risperidone usually results in cholestatic hepatitis and rare allergic symptoms; olanzapine induces hepatocyte damage, accompanied monocytes, centrolobular necrosis of lymphocytes, and eosinophils infiltration in the portal area; quetiapine is the leading cause of hepatocyte damage, extensive necrosis of hepatocytes, and nonspecific inflammatory infiltration; ziprasidone usually causes hepatocyte damage, hypersensitivity, eosinophilic and systemic symptoms drug-induced reaction syndrome; aripiprazole, paliperidone, aripiprazole, amisulpride have no relevant reports.
Grigoriadis, "Cholestatic Jaundice as a Paraneoplastic Manifestation of Prostate Adenocarcinoma," Clinical Gastroenterology and Hepatology, vol.
Use of everolimus in this post-liver transplant patient led to elevations in AST, ALT, and ALP consistent with mixed hepatocellular and cholestatic liver injury over a period of three months.
Stanozolol and testosterone propionate are part of the 17 alpha-alkylated (17aa) steroids that have been associated with cholestatic jaundice usually resolving after drug discontinuation [3].
A combination of laboratory tests was used to confirm drug-induced liver injury (hepatocellular, cholestatic, or mixed type) in 9 studies (50.0%), while either AST or ALT was used to confirm the same in 6 studies (33.3%), as shown in Table 2 (see supplement 2 and Table 1 for details).
A core needle biopsy of the liver was performed, which revealed inflammatory activity and apoptotic bodies spanning all zones of the liver, in keeping with acute cholestatic hepatitis, a pathological picture often related to drug-induced liver injury or nonhepatic viral infection (Figures 1 and 2).
However, cholestatic jaundice is an unusual presentation for UTI.