intrahepatic cholestasis of pregnancy

(redirected from cholestasis of pregnancy)

intrahepatic cholestasis of pregnancy

intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and icterus; of unknown cause but associated with high estrogen levels.

in·tra·he·pat·ic cho·le·sta·sis of preg·nan·cy

(in'tră-hĕ-pat'ik kō'lē-stā'sis preg'năn-sē)
Intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and/or icterus; of unknown cause but associated with high estrogen levels.
Synonym(s): cholestasis of pregnancy, recurrent jaundice of pregnancy.

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis
See also: cholestasis
References in periodicals archive ?
7, 2019 (HealthDay News) -- For women with intrahepatic cholestasis of pregnancy, treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes, according to a study published online Aug.
In a paper published in the journal 'The Lancet', it was found that 605 pregnant women with intrahepatic cholestasis of pregnancy (ICP) were recruited with half receiving ursodeoxycholic acid (known as 'urso'), the current drug used to treat the condition, and half a placebo.
(1) to assess the effect of intrahepatic cholestasis of pregnancy (ICP) upon newborn birthweight, we have concerns about the authors' interpretation of their findings because the birthweights in their meta-analysis were not corrected for gestational week or reported as a customised birthweight centile.
Vikki Meredith suffered from a liver condition called intrahepatic cholestasis of pregnancy (ICP), and as a result had one of the worst cases of itching.
Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best practice and research Clinical gastroenterology.
ABCB11 gene polymorphism and BSEP dysfunction were also involved in a variety of cholestatic disorders, including intrahepatic cholestasis of pregnancy (ICP), which manifested in the last trimester of pregnancy, and characterized by raised serum bile acid levels (17).
Her daughter Wren Ivy - who she had with co-star Jack Ashton - was born three weeks prematurely in September due to a condition called Intrahepatic cholestasis of pregnancy, in which there is a build-up of bile acids in the liver
George, who was diagnosed with a liver condition called ICP (intrahepatic cholestasis of pregnancy) which resulted in itching all over her body, from it is common for women to feel guilty about choosing to have a caesarean and there should be a national conversation to remove the stigma.
The 33-year-old had developed a liver condition called ICP (intrahepatic cholestasis of pregnancy), which is a build up of acid in the body that can cause premature or stillborn births.
However, no significant difference was noted in the rate of intrahepatic cholestasis of pregnancy between the study group and control group ( P > 0.05; [Table 2]).{Table 2}
Hereditary diseases characterised by hepatocanalicular cholestasis, which is caused by defects in hepatobiliary transporters, their regulator FXR, and in tightness of the liver epithelium, include progressive familial intrahepatic cholestasis (PFIC) types 1 to 5, benign recurrent intrahepatic cholestasis (BRIC) 1 and 2, familial cholelithiasis caused by a lack of biliary secretion of phospholipids (Low Phospholipid-Associated Cholelithiasis or Gallbladder Disease-1), intrahepatic cholestasis of pregnancy (ICP), and several other rare disorders.
The most important pregnancy-specific presentations are preeclampsia, eclampsia, hyperemesis gravidarum, AFLP, intrahepatic cholestasis of pregnancy, and HELLP syndrome [11,12].