and bile flow restoration and recovery from cholestasis occur much faster than improvement of hepatic microcirculation and recovery of IRI, which may diminish the informative relevance of ALP and GGT as markers of IRI.
In general it contributes to the release of some hormones elevates the activity of intestinal glutaminase stimulates the pancreas and choleresis
resists the oxidative injury of oxygen free radicals to biomembrane and increases the survival rate of cells.
It appears to increase choleresis
, with protection of cholangiocytes and hepatocytes.
ALE considerably increases choleresis in healthy volunteers (Kirchhoff et al.
Increase in choleresis by means of artichoke extract.
It is on record that 'following relief of biliary obstruction there is frequently a prompt and major choleresis
and bile volumes may exceed 4 liters per day.
UDCA is a hydrophilic, non-toxic bile acid that induces a choleresis
was two- to three-fold higher than that of cynarin.
High-dosed artichoke leaf extract (ALE) caused a considerable increase in choleresis
, most likely due to an increased bile production into the duodenum of healthy volunteers (Kirchhoff et al.
It seems that [alpha]-asarone induced clearance of cholesterol from the bloodstream and that the excess of hepatic cholesterol provided by LDL-cholesterol is diverted to bile sterol secretion via a bile choleresis
The increase in choleresis
associated with an increased formation of bile compounds has been shown in animal experiments (Frohlich and Mayr, 1973; Khadzhai and Kuznetsova, 1971; Lietti, 1977; Okamoto, 1940; Preziosi, 1962; Preziosi and Loscalco, 1956; Preziosi et al.
Kirchhoff R, Beckers CH, Kirchhoff G, et al (1994) Increase in choleresis
by means of artichoke extract.