cholecystokinin


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Related to cholecystokinin: enterogastrone, secretin

cholecystokinin

 [ko″le-sis″to-ki´nin]
a polypeptide hormone secreted in the small intestine, which stimulates gallbladder contraction and secretion of pancreatic enzymes.

cho·le·cys·to·ki·nin (CCK),

(kō'lē-sis-tō-kī'nin), [MIM*118440]
A polypeptide hormone (the human peptide has 33 residues) liberated by the upper intestinal mucosa on contact with gastric contents; stimulates contraction of the gallbladder and secretion of pancreatic juice.

cholecystokinin

(kō′lĭ-sĭs′tə-kī′nĭn)
n. Abbr. CCK
A hormone produced principally by the small intestine in response to the presence of fats, causing contraction of the gallbladder, release of bile, and secretion of pancreatic digestive enzymes. Also called pancreozymin.

cho·le·cys·to·ki·nin

(CCK) (kō'lĕ-sis'tō-kī'nin)
A polypeptide hormone liberated by the upper intestinal mucosa on contact with gastric contents; stimulates contraction of the gallbladder and secretion of pancreatic juice.

cholecystokinin

A HORMONE released into the blood from the lining of the duodenum when fat and acid are present. It causes the gallbladder to contract and the sphincter of Oddi to relax, so sending bile into the duodenum to emulsify the fat, and stimulates the pancreas to secrete fat- and protein-splitting enzymes. The hormone also inhibits the motility of the stomach and the secretion of gastric acid.

cholecystokinin (CCK) (formerly pancreozymin)

) a single hormone secreted by the wall of the duodenum in mammals when food enters the small intestine. CCK causes contraction of the gallbladder muscle, resulting in bile being pumped into the duodenum via the bile duct, and stimulates the pancreas to secrete pancreatic juice containing large quantities of digestive enzymes, which enter the duodenum via the lower part of the bile duct. CCK causes VASODILATION of the intestinal blood vessels.
References in periodicals archive ?
Cholecystokinin and peptide Y in yellowtail (Seriola quinqueradiata): Molecular cloning, real-time quantitative RT-PCR, and response to feeding and fasting.
Excessive drinking of alcohol and intake of high fat foods cause cholecystokinin receptor (CCKR) signaling pathways to induce intra-acinar activation of trypsinogen.
Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism.
Beglinger, "The effect of cholecystokinin in controlling appetite and food intake in humans," Peptides, vol.
Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment.
Similarly, receptors of other neuropeptides like somatostatin, neuropeptide Y, galanin, dynorphin, enkephalin, substance P, cholecystokinin, vasoactive intestinal polypeptide, hormones such as ghrelin, angiotensins, corticotropin-releasing hormone, adrenocorticotropin, thyrotropin-releasing hormone, oxytocin, and vasopressin involved in epilepsy [100].
Mechanisms of protein that act on food intake include slowing gastric emptying and direct or indirect stimulation of gastrointestinal hormones such as cholecystokinin and glucagon like peptide-1 [13].
Sulfated cholecystokinin octapeptide (CCK-8), lipopolysaccharide (LPS; Escherichia coli serotype O111:B4), aminoguanidine (AG), dexamethasone (DEX), pyrrolidine dithiocarbamate (pDTC), SQ-22,536, H-89, and forskolin were obtained from Sigma-Aldrich (St.
Proglumide (Pgm) is a known cholecystokinin (CCK) antagonist [29] and changes CCK level and receptor population of CCK has been associated with SE [30].
The related release and detection of nutrients in the small intestine was confirmed by blood serum levels of the hormone cholecystokinin.
What is known is that excessive concentrations of cholecystokinin (CCK) and peptide YY occur in critical illness, and that high levels are correlated with feed intolerance and slow gastric emptying.