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Male rats treated with 30 mg/kg bw furan for 3 months develop cholangiofibrosis, which in some cases progressed to tumors after 9 or 15 months without further treatment (Maronpot et al.
The NTP study also found evidence of other hepatotoxic responses after 2 years of chronic exposure to TCDD, including hepatocyte hypertrophy, multinucleated hepatocyte, diffuse fatty change, bile duct hyperplasia, bile duct cyst, oval cell hyperplasia, necrosis, pigmentation, inflammation, nodular hyperplasia, portal fibrosis, cholangiofibrosis, and toxic hepatopathy (NTP 2004a).