Interruption of normal signal transduction could impair cellular function, affecting bile formation and secretion by the cholangiocyte
Cyclooxygenase-2 (COX-2) also plays a role in the pathogenesis of CCA, activating growth factors that promotes cholangiocyte
growth, such as MAPK, epidermal growth factor receptor and interleukin 6.
Indeed, liver-derived exosomes induce hepatocyte and cholangiocyte
proliferation after injury [5, 6], can activate stellate cells , and spread hepatic metabolizing enzymes .
Strazzabosco, "Ursodeoxycholic acid stimulates cholangiocyte
fluid secretion in mice via CFTR-dependent ATP secretion," Gastroenterology, vol.
Cyclooxygenase-2 (COX-2) plays a role in the pathogenesis of CCA, activating growth factors that promotes cholangiocyte
growth, such as MAPK, epidermal growth factor receptor (EGFR) and interleukin 6 (IL-6), concluded the company.
Since IL-12-dependent, self-perpetuating autoimmune mechanism appears to be responsible for cholangiocyte
destruction, it is reasonable to expect a more progressive pace of the disease in patients who carry specific IL12RB2 polymorphisms.
[sup] We have learned that estrogens and their receptors influence the pathophysiology of cholangiocytes
and that this mainly occurs during experimental and human conditions characterized by cholangiocyte
injury and proliferation.
Liu et al., "MicroRNA-98 and let-7 confer cholangiocyte
expression of cytokine-inducible Src homology 2- containing protein in response to microbial challenge," Journal of Immunology, vol.
Polycystic liver diseases: Congenital disorders of cholangiocyte
MAPK signaling contributes to rotaviral-induced cholangiocyte
injury and viral replication.
Lau et al., "Hepatocellular carcinoma expressing cholangiocyte
phenotype is a novel subtype with highly aggressive behavior," Annals of Surgical Oncology, vol.