ALR is dysregulated in a number of solid tumors such as hepatocellular carcinoma, cholangiocellular
carcinoma (15), and colorectal cancer (9).
Exclusion criteria were (1) mixed HCC or cholangiocellular
carcinoma, (2) emergence of extrahepatic metastasis, (3) no R0 resection, (4) existence of another type of primary tumor, and (5) ever received chemotherapy, radiation therapy, or TACE before the surgery.
1995) and foci of cellular alteration, cortical tubular cysts lesions (renal system) (NTP, 2011) Chemical Level 4 * DEHP Hepatocarcinoma, cholan-giocellular tumors in male rats (standard bioassay male rats and PPARa-null mice), cholangiocellular
carcinoma (PPARa-null mice), hepatocarcinoma in female rats (standard bioassay), increased incidence of kidney tumors in rats (ini-tiation/promotion protocol) (Garvey et al.
It can arise at the hepatocellular level because of impairment of bile secretion by hepatocytes or at cholangiocellular
level, generally by obstruction of bile flow through intra- or extrahepatic bile ducts by gall stones or local malignancies .
Downregulation of organic cation transporter 1 (SLC22A1) is associated with tumor progression and reduced patient survival in human cholangiocellular
carcinoma," International Journal of Oncology, vol.
f) For liver tumors, updated classification used by QA and PWG pathologists and newer RI studies use hepatocellular adenoma/carcinoma descriptors, with those consisting of hepatocellular and cholangiocellular
elements now being diagnosed as hepatocholangiomas or hepatocholangiocarcinomas.
Thus, we will consider benign liver tumors of epithelial and nonepithelial origin, with the epithelial tumors further classified into tumors of either cholangiocellular
or hepatocellular origin.
Dysplasia of the biliary epithelium generated by bile stasis and chronic inflammation can develop a malignant transformation to cholangiocellular
carcinoma in 5% to 14% of patients with CD.
carcinoma and renal adenocarcinoma in a golden eagle (Aquila chrysaetos).
7%) (poorly differ-entiated adenocarcinoma in two cases, moderately differentiated adenocarcinoma in three cases, and well differentiated adenocarcinoma in one case) (Fig-3A), cholangiocellular
carcinoma in one case (11.
Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular
carcinoma cell lines.
Transforming growth factor [beta]1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular