cholangiocarcinoma


Also found in: Dictionary, Acronyms, Wikipedia.

cholangiocarcinoma

 [ko-lan″je-o-kahr″sĭ-no´mah]
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts, composed of eosinophilic cuboidal or columnar epithelial cells, with abundant fibrous stroma; mucus may be secreted but not bile.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kar'si-nō'mă),
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma; cirrhosis is usually absent.

cholangiocarcinoma

A rare (5/105/year) cancer of intrahepatic bile ducts, seen > age 60.
 
Aetiology
Anabolic steroids, liver flukes (Clonorchis sinensis), ulcerative colitis, cholecystitis, cholelithiasis, primary sclerosing cholangitis, malformations, cirrhosis.

Clinical findings
Obstruction, jaundice, abdominal pain, weight loss.

Location
Hilar, 50–60%; intrahepatic, 10%; extrahepatic 20–30%.

Prognosis
53% 1-year survival; 4% 5-year survival.

cholangiocarcinoma

Bile duct cancer, cancer of bile ducts A rare–5/100,000/yr cancer of intrahepatic bile ducts seen > age 60 Etiology Anabolic steroids, Thorotrast,.Clonorchis sinensis, possibly ulcerative cholitis, cholecystitis; not associated with alcohol abuse Clinical Jaundice—71%, abdominal pain-49%, weight loss—44% Prognosis 53% 1-yr survival, 9% 3-yr, 4% 5-yr. Cf Hepatocellular carcinoma.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kahr-si-nō'mă)
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma.

cholangiocarcinoma

Cancer of the bile ducts.
References in periodicals archive ?
The Company's lead TRuC-T cell product candidate, TC-210, is currently being studied in a Phase 1/2 clinical trial to treat patients with mesothelin-positive non-small cell lung cancer (NSCLC), ovarian cancer, malignant pleural/peritoneal mesothelioma, and cholangiocarcinoma.
HCC and Cholangiocarcinoma have very high recurrence, as much as 80% in five years12.
In the present study cohort of 76 patients with perihilar cholangiocarcinoma for >2 y, the >5-year-survival rate was 43.4% (>2-3 and >3-5-year-survival rate was 25.0% and 31.6%, respectively), with 14.5% of the patients surviving for >10 y after the surgery (Figure 1).
Primary Biliary Mucosa-associated Lymphoid Tissue Lymphoma Mimicking Hilar Cholangiocarcinoma. Korean J Gastroenterol 2016 Aug;68(2):114-118.
Patients with cholangiocarcinoma most often present with painless jaundice and other signs of biliary obstruction: scleral icterus, dark urine, clay-colored stools, or generalized pruritus.
Labianca, "Cholangiocarcinoma," Critical Reviews in Oncology/Hematology, vol.
Pairojkul et al., "Exome sequencing of liver fluke-associated cholangiocarcinoma," Nature Genetics, vol.
The diagnosis of cholangiocarcinoma in a choledochal cyst with hepatic metastases was retained.
Cholangiocarcinoma is most commonly diagnosed in the late eighth decade of life [4, 5].
Lee, "Clonal Epstein-Barr virus associated cholangiocarcinoma with lymphoepithelioma-like component," Human Pathology, vol.
These immunohistological results suggested "sarcomatous intrahepatic cholangiocarcinoma." The tumor was recurrent in 5 months after operation and unresectable.
US guided biopsy tissue obtained from the smaller right hepatic mass showed adenocarcinoma with an immunohistochemical profile consistent with cholangiocarcinoma. A CT scan of the chest showed multiple bilateral pulmonary nodules suspicious for metastasis.