chlorpropamide


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chlorpropamide

 [klor-pro´pah-mīd]
an oral sulfonylureahypoglycemic agent useful in treatment of type 2 diabetes mellitus in the adult whose condition is stabilized; it is contraindicated in patients with impairment of renal, thyroid, or hepatic function. Dosage is individually adjusted.

chlorpropamide

/chlor·pro·pa·mide/ (-pro´pah-mīd) a sulfonylurea used as a hypoglycemic in the treatment of type 2 diabetes mellitus.

chlorpropamide

(klôr-prō′pə-mīd′)
n.
A long-acting sulfonylurea drug, C10H13ClN2O3S, used to treat type 2 diabetes.

chlorproPAMIDE

[-prō′pəmīd]
an oral antidiabetic.
indication It is prescribed in the treatment of non-insulin-dependent diabetes mellitus.
contraindications Liver or kidney dysfunction or known hypersensitivity to this drug prohibits its use.
adverse effects Among the most serious adverse reactions are hematologic derangements and jaundice. Hypoglycemia, GI distress, and rashes are common adverse effects.

chlorpropamide

Endocrinology An oral sulfonylurea hypoglycemic, structurally related to tolbutamide, which ↑ release of insulin from beta islet cells in Pts with type 2 DM

chlorpropamide

long-acting sulphonylurea (oral hypoglycaemic) agent; used to treat younger non-obese patients with type 2 diabetes; also used to treat diabetes insipidus (sensitizes renal tubules to antidiuretic hormone)

chlorpropamide,

n brand names: Apo-Chlorpromide, Diabinese;
drug class: antidiabetic, first generation sulfonylurea;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
uses: stable type 2 diabetes mellitus.

chlorpropamide

a first generation sulfonylurea derivative, used as an oral hypoglycemic drug in the treatment of diabetes mellitus.
References in periodicals archive ?
c) Includes ami-doarone, carbamazepine, chlorpropamide, carbidopa/levodopa, heparin, interferon, lithium, phenytoin, phenobarbital, or sulfasalazine.
sarcoidosis, disorders of connective tissue (lupus SLE, rheumatoid arthritis, scleroderma), and adverse drug reactions (more than 50 drugs can cause fibrosis including 14 chemotherapy agents, sulfa, penicillin, furadantin, hydralazine apresoline, gold chlorpropamide, allopurinol, hydrochlorthiazide, and dilantin).
xx Actos, Amaryl, Avandamet, Avandia, chlorpropamide, Diabeta, Diabinese, Fortamet, Glipizide, Glipizide ER, Glipizide XL,Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glucovance, glyburide, glyburide micronized, glyburide-metformin, Glynase, Glyset, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L, Humulin N, Humulin R, Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin NPH, Lantus, Metaglip, metformin, metformin ER, Micronase, Novolin 70/30, Novolin L, Novolin N, Novolin R, Novolog, Novolog Mix 70/30, Prandin, Precose, Riomet, Starlix, tolazamide, tolbutamide, Tolinase, Velosulin Human BR ED = Erectile dysfunction; ICD-9-CM = International Classification of Diseases, 9th Edition, Clinical Modification; HCTZ = hydrochlorothiazide.
The sulfonylureas were kindly supplied by the following manufacturers: glibenclamide, glimepiride, and tolbutamide by Aventis (Paris, France); glipizide and chlorpropamide by Pfizer (Paris, France); gliclazide and carbutamide by Servier (Neuilly-sur-Seine, France); glibornuride by CSP (Cournon, France); and glisoxepide by Bayer (Puteaux, France).
The exceptions to this rule are chlorpropamide and glyburide, because both have prolonged half-lives and a tendency to cause hypoglycemia.
Table 2 Drugs Associated With the Development of PRCA * Antibiotic Isoniazid Cephalothin Chloramphenicol Dapsone Penicillin Antiepileptic Diphenylhydantoin Carbamazepine Sodium valproate Antiinflammatory Fenoprofen Sulfasalazine Cardiovascular Procainamide Chemotherapeutic Rifampicin Erythropoietic Recombinant erythropoietins Other agents Azathioprine Chlorpropamide Allopurinol Methazolamide Penicillamine Phenobarbital * Note: Adapted from Dessypris, E.
The primary treatment for nephrogenic DI is cessation of any causative agent and free water replacement, the administration of thiazide diuretics, and the administration of chlorpropamide, which may increase ADH release (Litwack, 1998).
Among the agents on the always-avoid list for elderly patients are meperidine, flurazepam, barbiturates, and chlorpropamide.
The Table 2 presents some results concerning: transdermal form of propranolol ([beta]-blocker) for treatment of patients with cardiovascular diseases; transdermal form of chlorpropamide (hypoglycemic medicine) for patients with non-insulin-dependent diabetes mellitus (Type II) [32]; in vitro results for transdermal form of insulin for patients with insulin dependent diabetes mellitus (Type I).
Diabetes Medications chlorpropamide (Diabenese) Treat type 2 diabetes by glipizide (Glucotol, Glucotrol XL) helping the pancreas glyburide (DiaBeta, Glynase, Micronase) release insulin into the blood stream.
Generic name Brand name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase, PresTab, Micronase tolazamide Tolinase tolbutamide Orinase
23] Patients with partial neurogenic DI may also benefit from the oral hypoglycemic agent, chlorpropamide, which stimulates the release of ADH from the pituitary gland and augments renal tubule response to ADH.