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a phenothiazine used in the form of the base or the hydrochloride salt as an antipsychotic agent, antiemetic, and presurgical sedative, and in the treatment of intractable hiccups, acute intermittent porphyria, tetanus, and the manic phase of bipolar disorder. It is also used to treat certain severe behavioral problems in children. Side effects include drowsiness and slight hypotension. In prolonged therapy the patient should be observed for jaundice. Some patients on long-term therapy develop persistent tardive dyskinesia.
chlorpromazine/chlor·pro·ma·zine/ (-pro´mah-zēn) a phenothiazine used in the form of the base or the hydrochloride salt as an antipsychotic, antiemetic, and presurgical sedative, and in the treatment of intractable hiccups, acute intermittent porphyria, tetanus, the manic phase of bipolar disorder, and severe behavioral problems in children.
A phenothiazine drug, C17H19ClN2S, usually given in its hydrochloride form and used chiefly to treat schizophrenia and other psychotic disorders, nausea and vomiting, and intractable hiccups.
a phenothiazine drug used as an antipsychotic and antiemetic.
indications It is prescribed in the treatment of psychotic disorders (mania, schizophrenia), severe nausea and vomiting, and intractable hiccups.
contraindications Parkinson's disease, concurrent administration of central nervous system depressants, liver or renal dysfunction, severe hypotension, or known hypersensitivity to this drug or to other phenothiazine medication prohibits its use.
adverse effects Among the more serious adverse effects are hypotension, alteration in cardiac conduction, liver toxicity, a variety of extrapyramidal reactions, blood dyscrasias, and hypersensitivity reactions.
chlorpromazineThorazine® An aliphatic phenothiazine, neuroleptic, antipsychotic, with antiadrenergic, anticholinergic, antiemetic, central antihypertensive activity
chlorpromazineA drug derived from phenothiazine used as an antipsychotic, a tranquillizer and to prevent vomiting (antiemetic). Historically, chlorpromazine was the first truly effective anti-psychotic drug. A brand name is Largactil.
chlorpromazineantipsychotic agent (Largactil) with antiadrenergic and anticholinergic actions; shows a wide range of adverse effects (e.g. extrapyramidal symptoms [drug-induced parkinsonism, dystonia, akathisia, tardive dyskinesia], hypotension, altered temperature regulation [hypothermia; hyperthermia], insomnia, agitation, convulsions); also used to control neuropathic and chronic pain states
a phenothiazine used as an antipsychotic agent and antiemetic. It has been largely superseded in veterinary work by acetylpromazine. Its principal use was as premedication for anesthesia.