chlorpromazine


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chlorpromazine

 [klor-pro´mah-zēn]
a phenothiazine used in the form of the base or the hydrochloride salt as an antipsychotic agent, antiemetic, and presurgical sedative, and in the treatment of intractable hiccups, acute intermittent porphyria, tetanus, and the manic phase of bipolar disorder. It is also used to treat certain severe behavioral problems in children. Side effects include drowsiness and slight hypotension. In prolonged therapy the patient should be observed for jaundice. Some patients on long-term therapy develop persistent tardive dyskinesia.

chlorpromazine

(klôr-prŏm′ə-zēn′, -prō′mə-)
n.
A phenothiazine drug, C17H19ClN2S, usually given in its hydrochloride form and used chiefly to treat schizophrenia and other psychotic disorders, nausea and vomiting, and intractable hiccups.

chlorpromazine

Thorazine® An aliphatic phenothiazine, neuroleptic, antipsychotic, with antiadrenergic, anticholinergic, antiemetic, central antihypertensive activity

chlorpromazine

A drug derived from phenothiazine used as an antipsychotic, a tranquillizer and to prevent vomiting (antiemetic). Historically, chlorpromazine was the first truly effective anti-psychotic drug. A brand name is Largactil.
References in periodicals archive ?
Antipsychotics Q1 (m/z) Q3 (m/z) DP (v) Chlorpromazine 319.1 86.1 65 319.1 214.1 60 319.1 246.1 57 Haloperidol 376.1 123.0 55 376.1 165.2 60 376.1 358.2 47 Levomepromazine 329.2 58.0 50 329.2 100.1 70 329.2 210.2 50 Olanzapine 313.2 198.2 45 313.2 256.0 62 313.2 169.1 53 Risperidone 411.2 191.2 80 411.2 110.1 55 411.2 82.2 54 Sulpiride 342.2 112.1 72 342.2 214.1 45 342.2 98.1 43 Repaglinide 453.3 230.2 32 453.3 174.2 35 Antipsychotics EP (v) CE(v) CXP (v) Chlorpromazine 10 32 4 15 30 3 10 25 4 Haloperidol 15 55 4 10 35 3 10 35 2 Levomepromazine 10 45 2 15 38 3 15 30 4 Olanzapine 20 30 3 15 35 2 20 40 2 Risperidone 20 40 3 20 30 2 10 38 3 Sulpiride 15 35 5 15 45 3 10 45 2 Repaglinide 10 43 3 15 45 3 Table 3: Recovery values at low, medium, and high levels.
Considering we compared different classifications of antipsychotic drugs by converting them to chlorpromazine equivalent, we were unable to discuss the correlations between the classifications of antipsychotic drugs and the different affected patterns of TD.
Promazine-induced lupus-like disease was similar to that disease already described for chlorpromazine and [Mn.sub.2+], because promazine also induces formation of NPA on liposomes like chlorpromazine or [Mn.sub.2+]; in fact, we have demonstrated that these lipid arrangements, NPA, are responsible for inducing the disease [4, 5, 25].
Among the typical antipsychotics used in the present study, chlorpromazine produced the greatest change in lipid profiles.
OBJECTIVE: To assess the response of psychogenic vomiting with conventional antipsychotic chlorpromazine.
Chlorpromazine and thioridazine are the mostly examined two drugs in this group.
The most utilized drugs in the facility studied that fall within the DU 90% segment, i.e., the drugs whose use accounted for about 90% of all the drugs used in the study site [Table 4], included: Amitriptyline (22.3%), trifluoperazine (20.3%), haloperidol (15.5%), chlorpromazine (15.2%), benzhexol (12.6%), and carbamazepine (7.9%).
Deniker and others hypothesized that the therapeutic activity of chlorpromazine was related to the ability of these medications to cause "specific neurological syndromes." (90) There had been theories in medicine concerning the use of "therapeutic diseases" as treatment.
Chlorpromazine (CPZ) is a tricyclic antidepressant that has been used as a sedative and antiemetic and for the management of psychotic disorders.
Antipsychotics were converted into chlorpromazine equivalents (Table 1).
In order to determine its efficacy in psychosis, we compared the effects of TMZ and chlorpromazine, a conventional antipsychotic drug, by evaluating the novelty-induced rearing and apomorphine-induced stereotypic behavior in rats.
Examples of TAP available in New Zealand are haloperidol, chlorpromazine and periciazine.