chloroquine


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Related to chloroquine: hydroxychloroquine, chloroquine phosphate

chloroquine

 [klor´o-kwin]
1. an antimalarial and antiprotozoal agent, also used as a lupus erythematosus suppressant.
2. an antiamebic and antiinflammatory agent used in treatment of malaria, giardiasis, non-intestinal amebiasis, lupus erythematosus, and rheumatoid arthritis; used as the base, hydrochloride salt, or phosphate salt.

chlor·o·quine

(klōr'ō-kwīn),
An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; available in phosphate and sulfate forms. It does not produce a radical cure because it has no effect on the exoerythrocytic stages; chloroquine-resistant strains of P. falciparum have developed in Southeast Asia, Africa, and South America. It is also used for hepatic amebiasis and for certain skin diseases, for example, lupus erythematosus and lichen planus.

chloroquine

(klôr′ə-kwīn′, -kwēn′)
n.
A drug, C18H26ClN3, used usually in its phosphate form to prevent and treat malaria and to treat amebiasis that has spread outside the intestines.

chlor·o·quine

(klōr'ō-kwīn)
An antimalarial agent used for the treatment and suppression ofPlasmodium vivax, P. malariae, and P. falciparum; available in phosphate and sulfate forms. It is also used for hepatic amebiasis and for certain skin diseases, e.g., lupus erythematosus and lichen planus.

chloroquine

A drug used in the treatment of MALARIA, RHEUMATOID ARTHRITIS and lupus erythematosus. In 1993 the clinical effectiveness of chloroquine in Malawi was less than 50 percent and it was replaced by sulfadoxine and pyrimethamine. But ten years late the efficiency had risen again to 99 percent. The drug is on the WHO official list. Brand names are Avoclor and Nivaquine.

Chloroquine

An antimalarial drug that was first used in the 1940s, until the first evidence of quinine resistance appeared in the 1960s. It is now ineffective against falciparum malaria almost everywhere. However, because it is inexpensive, it is still the antimalarial drug most widely used in Africa. Native individuals with partial immunity may have better results with chloroquine than a traveler with no previous exposure.
Mentioned in: Malaria

chlor·o·quine

(klōr'ō-kwīn)
An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; also used for hepatic amebiasis and some skin diseases.
References in periodicals archive ?
[USA], Nov 16 ( ANI ): According to previous researches, anti-malaria drugs known as chloroquines were repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor.
dirus mosquitoes with blood collected from these patients on 3 occasions: 1) before the first dose of DHA/PPQ or chloroquine, 2) on the same day at 9:00 pm (i.e., 2-11 h after treatment), and 3) at 24 h posttreatment for patients treated with chloroquine.
The next important step is to test the efficacy of Chloroquine in combination with glutaminolysis inhibitors in a clinical trial."
2014 Dec; 132[12]: 1453-60), and a ceiling of 2.3 mg/kg per day actual body weight for chloroquine.
The drugs (20 mg/kg Chloroquine, 20 mg/kg Compound 1 and 20 mg/kg Compound 2 in fundamental state for a 20 g of mouse weight) were orally administered 72 hours post-inoculation during 4 days, using a metylcellulose (1 %) and Tween 80 (0.5 %) as vehicle.
The plate was predosed with the test compounds at eight final concentrations in the concentration ranges of 2.74-350 [micro]M (piperine), 1.63-200 nM (mefloquine), 3.9-500 nM (chloroquine), and 0.39-50 nM (artesunate).
Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change," The American Journal of Tropical Medicine and Hygiene, vol.
Results: The results showed 100% efficacy of chloroquine in treating uncomplicated malaria caused by Plasmodium vivax in children.
DISCUSSION: Chloroquine is an antimalarial drug of 4-aminoquinolines group.
Chloroquine has to be present in the bloodstream for a prolonged period and at a relatively high dose for there to be a significant risk of developing retinopathy.
Macular sensitivity changes for detection of chloroquine toxicity in asymptomatic patient.
Chloroquine (CQ) was introduced widely throughout the world due to its effectiveness, low cost, and relative safety as compared to other antimalarial drugs [3].