During the 1950s and 1960s, a plethora of new psychoactive substances were registered to treat conditions such as anxiety and depression, including antipsychotics such as chlorpromazine, antidepressant (imipramine), and a range of sedative-hypnotics such as ethchlorvynol, chlormethiazole
, meprobamate, methaqualone, and glutethimide.
CYP2E1 inhibition by chlormethiazole
(Lu et al., 2008; Wang et al., 2009) or diallyl disulfide (Shimada et al., 2006) ameliorated ethanol-induced pathological changes.
Inclusion criteria for participants were 2-fold: a) only clinically healthy males with normal hepatic function test values were included, and b) only those not taking drugs that alter CYP2E1 activity (e.g., acetaminophen, isoniazid, disulfiram, chlormethiazole
, or chloroquine) were included (Frye and Branch 2002; Park et al.
We took morphine, diamorphine, cyclozine, codeine, temazepam, nitrezepam, phenobarbitone, sodium amytal dextropropoxyphene, methadone, nalbuphine, pethidine, pentazocine, buphrenorphine, dextromoramide chlormethiazole
. The streets are awash with drugs you can have for unhappiness and pain, and we took them all.
A study of the psychometric effects of chlormethiazole
in healthy young and elderly subjects.
The Forum warned doctors against doling out the drug chlormethiazole
- commonly prescribed - because it could cause respiratory failure when combined with alcohol.