CLCN5

(redirected from chloride channel 5)

CLCN5

A gene on chromosome Xp11.23-p11.22 that encodes a member of the voltage-gated chloride channel and ion transporters.

Molecular pathology
CLCN5 mutations have been found in Dent disease and renal tubular disorders with nephrolithiasis.
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References in periodicals archive ?
1551) investigated the effects of Cd on the expression of megalin and chloride channel 5 (C1C5), two key proteins involved in albumin-receptor-mediated endocytosis.
OBJECTIVES: To gain insights into the mechanisms of Cd-induced albuminuria, we investigated effects of Cd on the expression of megalin and chloride channel 5 (ClC5), two key players in albumin-receptor--mediated endocytosis.
Albumin endocytosis requires a macromolecular protein complex formed by the megalin/cubilin scavenger receptor [Na.sup.+]-[H.sup.+] exchanger isoform 3 (NHE3), vacuolar proton-ATPase (v-[H.sup.+]-ATPase), and chloride channel 5 (ClC5).