CLCN3

(redirected from chloride channel 3)

CLCN3

A gene on chromosome 4q33 that encodes a voltage-gated chloride channel that mediates exchange of chloride ions for protons, acting as as antiporter and contributing to acidification of endosomal and synaptic vesicle lumina; it thus may affect vesicle trafficking and exocytosis. CLCN3 may play a role in neuronal cell function by regulating membrane excitability by protein kinase C, and may have a role in short-term memory.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Researchers found that in both Type I and Type II macrophages, the added 1a,25-dihydroxyvitamin D3 played a key role in opening a specific chloride channel called "chloride channel 3 (CLC3)," which is important in supporting the uptake of amyloid beta through the process known as phagocytosis.