Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Chlor-Trimeton Allergy 4 Hour(trade name),
Chlor-Trimeton Allergy 8 Hour(trade name),
Chlor-Trimeton Allergy 12 Hour(trade name),
PediaCare Allergy Formula(trade name),
Pregnancy Category: B
ClassificationTherapeutic: allergy cold cough remedies
Relief of allergic symptoms caused by histamine release, including:
- Nasal allergies,
- Allergic dermatoses.
Antagonizes the effects of histamine at H2-receptor sites; does not bind to or inactivate histamine.
Decreased symptoms of histamine excess (sneezing, rhinorrhea, nasal and ocular pruritus, ocular tearing, and redness).
Absorption: Well absorbed following oral and parenteral administration.
Distribution: Widely distributed. Minimal amounts excreted in breast milk. Crosses the blood-brain barrier.
Metabolism and Excretion: Extensively metabolized by the liver.
Half-life: 12–15 hr.
Time/action profile (antihistaminic effects)
|PO||15–30 min||6 hr||4–12 hr|
Contraindicated in: Hypersensitivity; Acute attacks of asthma; Lactation: Avoid use or use alternative feeding method; Known alcohol intolerance (some liquid forms); Pediatric: Children <4 yr (OTC cough and cold products containing this medication should be avoided).
Use Cautiously in: Angle-closure glaucoma; Liver disease; Geriatric: Appears on Beers list. Geriatric patients are more susceptible to adverse reactions due to anticholinergic effects; Obstetric: Safety not established.
Adverse Reactions/Side Effects
Central nervous system
- drowsiness (most frequent)
- excitation (in children)
Ear, Eye, Nose, Throat
- blurred vision (most frequent)
- hypertension (most frequent)
- dry mouth (most frequent)
- urinary hesitancy
Drug-Drug interaction↑ CNS depression with other CNS depressants, including alcohol, opioid analgesics, and sedative/hypnotics.MAO inhibitors intensify and prolong anticholinergic effects of antihistamines.↑ anticholinergic effects with other drugs possessing anticholinergic properties, including antidepressants, atropine, haloperidol, phenothiazines, quinidine, and disopyramide.
Oral (Adults) 4 mg q 4–6 hr or 8–12 mg of extended-release formulation q 8–12 hr (not to exceed 24 mg/day).
Oral (Geriatric Patients) 4 mg twice daily or 8 mg of extended-release formulation at bedtime.
Oral (Children 6–12 yr) 2 mg 3–4 times daily (not to exceed 12 mg/day).Injectable formulation is available only in Canada
Subcutaneous Intramuscular Intravenous (Adults) 5–40-mg single dose (not to exceed 40 mg/day).
Subcutaneous (Children) 87.5 mcg (0.0875 mg)/kg or 2.5 mg/m2 q 6 hr as needed.
Availability (generic available)
Tablets: 4 mgRx, OTC, 8 mgRx, OTC, 12 mgRx, OTC
Chewable tabletsorange flavor: 2 mgRx, OTC
Timed-release tablets: 8 mgRx, OTC, 12 mgRx, OTC
Timed-release capsules: 8 mgRx, OTC, 12 mgRx, OTC
Syrup: 1 mg/5 mLRx, OTC, 2 mg/5 mLRx, OTC
Injection: 10 mg/mL, 100 mg/mLIn combination with: hydrocodone (Tussionex),, hydrocodone and pseudoephedrine (Zutripro), and decongestantsRx, OTC. See combination drugs.
- Assess allergy symptoms (rhinitis, conjunctivitis, hives) prior to and periodically during therapy.
- Monitor pulse and BP before initiating and throughout IV therapy.
- Geriatric: Assess for adverse anticholinergic effects (delirium, acute confusion, dizziness, dry mouth, blurred vision, urinary retention, constipation, tachycardia).
- Assess lung sounds and character of bronchial secretions. Maintain fluid intake of 1500–2000 mL/day to decrease viscosity of secretions.
- Lab Test Considerations: May cause false-negative reactions on allergy skin tests; discontinue 4 days prior to testing.
Potential Nursing DiagnosesIneffective airway clearance (Indications)
Risk for injury (Adverse Reactions)
- Oral: Administer oral doses with food or milk to decrease GI irritation. Extended-release tablets and capsules should be swallowed whole; do not crush, break, or chew. Chewable tablets should not be swallowed whole; chew well before swallowing.
- Subcutaneous: Intramuscular: The 100-mg/mL solution is recommended for IM or subcut routes only. The 10-mg/mL solution may be used for IM, subcut, or IV.
- pH: No Data.
- Diluent: May be given undiluted. Use only the 10 mg/mL strength for IV administration. Concentration: 10 mg/mL.
- Rate: Administer each 10-mg dose over at least 1 min.
- Instruct patient to take chlorpheniramine as directed.
- Caution parents to avoid OTC cough and cold products while breastfeeding or to children <4 yrs.
- Geriatric: Teach patient and family about anticholinergic effects and to contact health care professional if effects persist.
- May cause drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to drug is known.
- Caution patient to avoid using alcohol or other CNS depressants concurrently with this drug.
- Advise patient that good oral hygiene, frequent rinsing of mouth with water, and sugarless gum or candy may help relieve dryness of mouth.
- Instruct patient to contact health care professional if symptoms persist.
- Decrease in allergic symptoms.
A salt of chloric acid.
A salt of chloric acid.