chiral inversion

chiral inversion

A metabolic process which requires enzyme activity to convert one enantiomeric form into the other.  Metabolic enzymes can:
(1) introduce a stereogenic centre into a non-chiral molecule to form enantiomeric metabolites;
(2) alter a ligand attached to a stereogenic centre with either retention or inversion of chirality;
(3) introduce an additional stereogenic centre into a chiral molecule to produce diastereomeric metabolites;
(4) convert a pair of enantiomers into a common metabolite by removal of a stereogenic centre; or
(5) convert one enantiomeric form into the other.
References in periodicals archive ?
MD simulations were also employed by Jordan and Crespi [32] to study the mechanical chiral inversion of closed CNCs.
The S(+) isomer, due to chiral inversion dominated in cats, dogs and horses.
Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide.