chimerism


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Related to chimerism: blood chimerism

chimerism

 [ki´mer-izm]
the state of being a chimera; the presence in an individual of cells of different origin.

chi·me·rism

(kī-mēr'izm),
The state of being a chimera.

chimerism

(kī-mîr′ĭz′əm, kī′mə-rĭz′-)
n.
The condition of being a genetic chimera.

chimerism

[kimir′izəm]
a state in bone marrow transplantation in which bone marrow and host cells exist compatibly without signs of graft-versus-host rejection disease.

chimerism

the state of being a chimera; the presence in an animal of cells of different origin, e.g. XX/XY chimerism.

blood chimerism
twins that have a common circulation develop immune tolerance. Each of them is then a chimera. When the twins are of opposite sex, the female twin may be a freemartin. Sterilization of the female is brought about by the transfer of H-Y antigen to the female gonad.
References in periodicals archive ?
Single nucleotide polymorphism-based system improves the applicability of quantitative PCR for chimerism monitoring.
In the past, the drawback to using STR analysis for chimerism quantification and monitoring was the cumbersome process of analyzing fragment data-determining fragment sizes, usually in one program, manually determining informative loci, and then transferring results to a spread sheetfor quantification and monitoring.
However, while allorecognition in Botryllus appears to be promoting highly discriminatory fusion events, to date no clear advantage to chimerism has been documented (reviewed in Rinkevich and Weissman, 1992; De Tomaso, 2006).
Patients: Patients were evaluated in two categories: [1] Twenty-eight transplants with at least one-year follow-up postHSCT were evaluated for the long-term follow-up of MC, and (2) Twenty transplants within this group with chimerism evaluation done both at the 1st month and the 3rd month postHSCT were evaluated for the evolution of early MC detected at the 1st month postHSCT.
Plasma DNA can serve as an alternative sample type for the determination of HSCT chimerism (20) and as a potential marker for monitoring graft rejection or other sources of tissue damage after solid-organ transplantation (19, 25, 26).
Despite the full chimerism and the presence of GVHD, an isolated extramedullary relapse after transplantation occurred in our case.
Three of ten patients were positive for the presence of CB001 cells at day 7; however, there was no chimerism contribution from CB001 between days 21-28.
Chimerism may eventually render the recipient tolerant to cell, tissue or organ transplants from the same donor, thereby enabling transplant patients to discontinue immunosuppressive medications after building stable immunological tolerance.
Origin and outcome of pregnancies affected by androgenetic/biparental chimerism.
It should be remembered that although the majority of such individuals are hemizygous males, heterozygous females, depending on their chimerism,may have G6PD deficiency in as many as 80% of their erythrocytes.
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation.
Genetically nonhomogenous entities can be established by chimerism (a situation where an organism possesses cells simultaneously derived from at least two genetically distinct conspecifics) or by a mosaicism (production of an organism with genetically different cells that derived from a single zygote lineage).