chimerin 2

chimerin 2

A protein encoded by CHN2 on chromosome 7p15.3, a GTPase-activating protein that plays a role in smooth muscle cell proliferation and migration, which is regulated by phospholipid binding. Binding of diacylglycerol (DAG) induces translocation of chimerin from the cytosol to the Golgi membrane.
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A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men.
Lu et al., "Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients," Journal of Diabetes and Its Complications, vol.