chimeric protein

A hybrid protein encoded by a nucleotide sequence spliced together from 2+ complete or partial genes produced by recombinant DNA technology

chimeric protein

see fusion protein.
References in periodicals archive ?
The corresponding EML4ALK chimeric protein demonstrated constitutive tyrosine kinase activity that conferred transformation potential and responsiveness to specific targeted inhibitors in vitro and in vivo.
Expression of a chimeric protein containing the catalytic domain of shiga-like toxin and human granulocyte macrophage colony-stimulating factor (Hgm-csf) IN Escherichia coli and its recognition by reciprocal antibodies.
Recent advances in molecular methodologies have allowed gene fusions and chimeric protein construction.
The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.
The chimeric protein contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein that contains a protein transduction domain (PTD) or a fragment thereof having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment that contains a J-domain or a fragment thereof having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment that contains a target protein or polypeptide.
This chimeric protein reveals what parts of GLUT4 play a role in indinavir's inhibition of glucose absorption.
ECI's hypothesis is that ECI characterized Protector Proteins alphaA-Crystallin, gammaD-Crystallin and the chimeric protein, pepstatin /leupeptin/alphaA-Crystallin, will inhibit the proteolytic enzymes secreted by the host and the pathogen, thus serving as a good therapeutic agent against the management of microbial keratitis.
The high efficiency of protein expression obtained with this particular bgh-polyA signal became apparent as we subsequently documented its efficiency in a wide range of chimeric protein expression systems, both in vivo and in vitro.
Although most of the autoreactive epitopes of GAD65 are located within the middle and the C-terminal regions of GAD65 (amino acids 245-585) (27, 34), truncated GAD65 lost almost all of its autoreactive epitopes when it was integrated in a chimeric protein with IA2c (Fig.
This gene fusion is postulated to produce an oncogenic chimeric protein with the zinc finger DNA-binding domains of WT1 with the transcriptional regulatory domain of the Ewing sarcoma gene.