chimeric molecule

chi·mer·ic mol·e·cule

a molecule (usually a biopolymer) containing sequences derived from two different genes; specifically, from two different species. Compare: chimera.
References in periodicals archive ?
TBR-760 is a dopamine-somatostatin chimeric molecule that inhibits NFPA cell proliferation and has the potential to shrink or halt tumor growth.
Some of the shark antigen-binding domains were subsequently engineered into a human immunoglobulin framework, producing a chimeric molecule. At the top left of the painting (Fig.
Our study shows that in translational fusion the active domains of both Cry1Ac and Hvt remained intact and this translational fusion is highly effective chimeric molecule against agronomically important insects, which should be evaluated further for use as biopesticides or introduced in crop plants especially cotton for long lasting transgenic protection against herbivorous insects.
The similarity of these clusters to nascent junctional plaques was more easily assessed by employing a chimeric molecule containing both the E-cadherin extracellular domain and a desmosomal cadherin cytoplasmic domain.
4D, lane P) had not only a 307-bp wild-type band but also carried a 281-bp chimeric molecule, which was inherited from the mother (Fig.
Our cases showed that the allele dropout was related to the presence of chimeric molecules. The PCR product for the CYP21 gene would be the major product, and because of the PCR competition reaction, there is very little chimeric CYP21P/CYP21 product.
Eshhar, "Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity," in Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Eshhar, "Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity," Proceedings of the National Academy of Sciences of the United States of America, vol.
Design, synthesis and bioactivity of catechin/ epicatechin and 2-azetidone derived chimeric molecules. Bioorganic & Medicinal Chemistry Letters, v.19, p.7007-7010, 2009.
So you have a molecule that essentially is genetically engineered and stitches together two different disparate kinds of activities so we have chimeric molecules.
The drug discovery research collaboration is expected to focus on Yale's work on proteolysis targeting chimeric molecules (PROTACs), attempting to show that they can be turned into medicines.
To examine the reaction of these three distinct chimeric molecules to TaqI digestion, the 6.1-kb PCR product was directly subjected to TaqI cleavage analysis.