chimera

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chimera

 [ki-me´rah]
an organism whose body contains different cell populations derived from different zygotes of the same or different species, occurring spontaneously or produced artificially.

chi·me·ra

(kī-mēr'ă, ki-),
1. In experimental embryology, the individual produced by grafting an embryonic part of one animal onto the embryo of another, either of the same or of another species.
2. An organism that has received a transplant of genetically and immunologically different tissue, such as bone marrow.
3. Dizygotic twins that exchange immunologically distinct types of erythrocytes.
4. A protein fusion in which two different proteins are linked through peptide bonds; usually genetically engineered. Chimeric antibodies may have the Fab fragment from one species fused with the Fc fragment from another.
5. Any macromolecule fusion formed by two or more macromolecules from different species or from different genes.
[L. Chimaera, G. Chimaira, mythic monster (lit. a she-goat)]

chimera

/chi·me·ra/ (ki-mir´ah)
1. an organism with different cell populations derived from different zygotes of the same or different species, occurring spontaneously or produced artificially.
2. a substance created from proteins or genes of two species, as by genetic engineering.chimer´ic

chimera

also

chimaera

(kī-mîr′ə, kĭ-)
n.
1.
a. An organism, organ, or part consisting of two or more tissues of different genetic composition, produced as a result of organ transplant, grafting, or genetic engineering.
b. A gene or protein consisting of parts from two different genes or proteins that are normally distinct, sometimes derived from two different species.
2. An individual who has received a transplant of genetically and immunologically different tissue.

chimera

[kimir′ə, kīmir′ə]
Etymology: Gk, khimaros, fire-breathing monster
an organism carrying cell populations derived from two or more different zygotes of the same or different species. Chimeras include recipients of tissue grafts from other individuals. Compare mosaic.

chimera

Any individual organism or molecule derived from 2 or more species.
 
Embryology
An organism that results when an embryonic part of one organism is grafted onto another.

Genetics
An organism with 2 or more cell lines, genotypes or karyotypes descended from at least 2 zygotes. Chimeras are very rare, only occur in twins and result from chorionic vascular anastomoses, transplantations or double fertilisations and subsequent participation of both fertilised meiotic products in one developing embryo; all hermaphrodites should be karyotyped to evaluate possible chimerism.

Molecular biology
(1) An animal formed from two different embryonic sources. In mouse genetics, targeted mutations produced in embryonic stem cells are recovered by breeding chimeric mice, resulting from the mixture of embryonic stem cells with a genetically distinct blastocyst.
(2) A clone containing genomic DNA from nonadjacent genomic segments or cDNA from two different mRNAs.

Transplantation
The term chimera was once used for a person who had received transplanted tissue—e.g., bone marrow surviving in a recipient.

chi·me·ra

(kī-mēr'ă)
1. The individual produced by grafting an embryonic part of one animal onto the embryo of another, either of the same or of another species.
2. An organism that has received a transplant of genetically and immunologically different tissue, such as bone marrow.
3. Dizygotic twins that have immunologically distinct types of erythrocytes.
4. A protein fusion in which two different proteins, usually from different species, are linked through peptide bonds; usually genetically engineered. Chimeric antibodies may have the Fab fragment from one species fused with the Fc fragment from another.
5. Any macromolecule fusion formed by two or more macromolecules from different species or from different genes.
[L. Chimaera, G. Chimaira, mythic monster (lit. a she-goat)]

chimera

An organism that contains a mixture of genetically different cells derived from more than one ZYGOTE. A chimera may, for instance, occur as a result of fertilization by more than one spermatozoon; fusion of two zygotes; an ALLOGENEIC bone marrow graft; cell exchange between dizygotic twin fetuses; or combination of portions of embryos of different species. Compare MOSAICISM. The term derives from the name of a mythical monster with a lion's head, a goat's body, and a serpent's tail.

chimera, chimaera

1. a mythological, fire-spouting monster with a lion's head, goat's body and serpent's tail.
2. an animal whose body contains different cell populations derived from different zygotes of the same or different species, occurring spontaneously or produced artificially; i.e. an individual composed of a mixture of genetically different cells.

chimera protein
see fusion protein.
References in periodicals archive ?
Rhone-Poulenc Agrochimie (Ongar, United Kingdom) has patented plant cells transformed by: (i) transforming a plant cell whose growth is sensitive to inhibition by a sulfonamide or a salt thereof with a chimaeric gene comprising (a) a plant promoter, (b) a sulfonamide resistance gene having a sequence encoding a transit peptide fused to the 5'-end of the resistance gene and (c) a plant polyadenylation/terminator sequence; (ii) selecting a transformed plant cell whose growth is resistant to inhibition by a sulfonamide or salt thereof; (iii) optionally, regenerating from the transformed plant cell a genetically transformed plant which exhibit the said resistance; (iv) optionally, obtaining seed from the regenerated plant; and (v) optionally, propagating plants from the seed.
The great majority of approved monoclonal antibodies that are on the market today are chimaeric and humanised monoclonal antibodies, with 17 antibodies approved for commercial sale in one or more commercial territory.
Crystallization and preliminary X-ray diffraction study of a chimaeric Fab' fragment of antibody binding tumour cells.
This activity has been confirmed in several in vivo proof of concept studies of the rodent and chimaeric precursor molecules to PG102, including a model of multiple sclerosis.
patent protection for its novel Chimaeric Virus Particle (CVP) technology, EPICOAT(R) -- from which the company is developing a new generation of plant derived vaccines which target mucosal immunity -- on the day they have signed their first agreement with a major Life Sciences company.
Using its patented EPICOAT(R) technology, Axis Genetics has produced Chimaeric Virus Particles (CVP) which present MUC-1 derived peptides on the plant virus surface.