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Any individual organism or molecule derived from 2 or more species.
An organism that results when an embryonic part of one organism is grafted onto another.

An organism with 2 or more cell lines, genotypes or karyotypes descended from at least 2 zygotes. Chimeras are very rare, only occur in twins and result from chorionic vascular anastomoses, transplantations or double fertilisations and subsequent participation of both fertilised meiotic products in one developing embryo; all hermaphrodites should be karyotyped to evaluate possible chimerism.

Molecular biology
(1) An animal formed from two different embryonic sources. In mouse genetics, targeted mutations produced in embryonic stem cells are recovered by breeding chimeric mice, resulting from the mixture of embryonic stem cells with a genetically distinct blastocyst.
(2) A clone containing genomic DNA from nonadjacent genomic segments or cDNA from two different mRNAs.

The term chimera was once used for a person who had received transplanted tissue—e.g., bone marrow surviving in a recipient.


  1. (also called graft-hybrid) an organism, usually a cultivated plant, whose tissues are of more than one genetical type as a result of mutation or grafting.
  2. a smooth-skinned cartilaginous deep-sea fish (‘king of the herrings’) of the subclass Holocephali, which were common in the Jurassic.
  3. a DNA hybrid molecule: a composite DNA molecule produced by GENETIC ENGINEERING, made up of DNA fragments from more than one organism. It is named after the Chimaera of Greek mythology, a beast with the head of a lion, the body of a goat and the tail of a serpent.

chimera, chimaera

1. a mythological, fire-spouting monster with a lion's head, goat's body and serpent's tail.
2. an animal whose body contains different cell populations derived from different zygotes of the same or different species, occurring spontaneously or produced artificially; i.e. an individual composed of a mixture of genetically different cells.

chimera protein
see fusion protein.
References in periodicals archive ?
Sharks, rays and chimaeras tend to grow slowly and produce few young, which leaves them particularly vulnerable to overfishing," said Sonja Fordham, IUCN SSG Deputy Chair and president of the Washington, DC-based Shark Advocates International, a project of The Ocean Foundation.
Paolo said: "It's a beautiful TVR Chimaera four-litre - a burgundy soft-top with a cream leather interior.
Earlier this week, ANZ had decided not to invest USD55m in Melbourne-based Chimaera in order to bail out the stock lender.
The 'descriptive' stage should be concluded both as a 'narration' about Ars Chimaera, and as a narration, which is provided by the trend proper--one that helps it exist in the realm of art.
Modern cars in the firms range include the TVR Chimaera 4.
The TVR Chimaera, with its leather interior and throbbing V8 engine, had almost tempted me.
Animals of literally all kinds are put together: the expected unicorns and dragons (the latter, evidently among the writer's favorites, are even carefully classified and divided into ten subspecies), the classical chimaera and sphinx and a would-be classical new entry such as the acromantula, animals deriving from local folk-lore such as the pixie, the mooncalf, the kelpie and the leprechaun, and a number of animals invented for the occasion: among the most notable instances we find the dugbog, the pogrebin, the bowtruckle, and the lobalug.
Littlevisited beaches and unspoilt coastal scenery are seen en route, along with Phaselis, a wonderfully preserved Graeco-Roman site, before winding south to Chimaera - the eternal flame of legend - and the nearby ruins of Olympus.
I used to have an MG Midget, which I polished to death, and now I have a yellow TVR Chimaera, with a five-litre engine.
It is not merely post-Leavism without the bore of having to study texts one has not already read, it is also a substitute for the Social Sciences, a pick-and-mix sociology that veers away from the dangerous chimaera of system and comprehensiveness.
A revolutionary new printing process for leather has been pioneered on the upholstery of a TVR Chimaera, and may eventually be seen on all home and fashion accessory leather goods.
I also cannot refrain from mentioning that I had the enormous pleasure in 1987 of finding a first edition of Hilarotragoedia, complete with its original dust-jacket consisting in a photo of Manganelli wearing a fedora and looking like a detective, in the Chimaera Bookstore in Palo Alto