Chili Pepper

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capsicum

(kap-si-kum) ,

Capzasin-HP

(trade name),

Zostrix

(trade name),

capsaicin

(trade name),

chili pepper

(trade name),

African bird pepper

(trade name),

Capsicum annuum

(trade name)

Classification

Therapeutic: analgesics
Oral: Dyspepsia Topical: Arthritis, lower back pain, and neuralgias Intranasal: Headache, perennial rhinitis

Action

Binds to nociceptors in the skin, causing neuronal excitation, heightened sensitivity and cutaneous vasodilation. Initially, a burning or pricking sensation is produced. With repeated use, a period of desensitization occurs caused by substance P depletion.

Therapeutic effects

Decreased pain sensation.

Pharmacokinetics

Absorption: Well absorbed when applied to skin.
Distribution: Unknown.
Metabolism and Excretion: Metabolized by the cytochrome P450 system to active metabolites.
Half-life: 1.6 hrs (topical).

Time/action profile

ROUTEONSETPEAKDURATION
POUnknownUnknownUnknown
TopicalUnknownUnknownUnknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity or allergy; Injured skin or open wounds (topical); Infectious or inflammatory GI conditions (oral); Obstetric: Pregnancy and lactation (oral).
Use Cautiously in: Obstetric: Pregnancy and lactation (topical); Pediatric: Safety and efficacy has not been shown in children; Kidney and/or liver disease (long-term, high doses); Surgery (discontinue use 2 wk prior to procedure).

Adverse Reactions/Side Effects

Dermatologic

  • burning (topical)
  • erythema (topical)
  • urticaria (topical)
  • flushing
  • sweating

Ear, Eye, Nose, Throat

  • cough
  • rhinorrhea
  • lacrimation,

Gastrointestinal

  • GI irritation
  • diarrhea

Hematologic

  • bleeding

Interactions

May ↑ bleeding risk with antiplatelet agents or anticoagulants.May ↑ absorption of theophylline.May ↑ bleeding risk when taken with clove, garlic, ginger, ginseng, and ginkgo.
Oral (Adults) Powder—30–120 mg 3 times daily; Tincture—0.6–2 mL/dose; Oleoresin—0.6–2 mg/dose.
Topical (Adults) Apply cream 3 to 4 times daily (may take up to 14 days to see an effect).
Intranasal (Adults) 0.1 mL of a 10 mM suspension (300mcg/day) applied to nostril.

Availability

Powder:
Capsules:
Tincture:
Topical cream: 0.025% (Zostrix®), 0.075% (Zostrix-HP®), 0.1% (Capzacin-HP®)

Nursing implications

Nursing assessment

  • Assess pain intensity and location before and periodically during therapy.
  • Lab Test Considerations: Monitor: liver and kidney function tests in patients receiving oral therapy. Notes: Capsicum (or cayenne) alters temperature regulation and stimulates circulation.

Potential Nursing Diagnoses

Acute pain (Indications)

Implementation

  • Topical: Apply to affected area not more than 3–4 times daily. Avoid getting medication into eyes or on broken or irritated skin. Do not bandage tightly.
    • Topical lidocaine may be applied during the first 1–2 wk of treatment to reduce initial discomfort.

Patient/Family Teaching

  • Instruct patient on the correct method for application. Rub cream into affected area well so that little or no cream is left on the surface. Gloves should be worn during application or hands should be washed immediately after application. If application is to hands for arthritis, do not wash hands for at least 30 min after application.
  • Advise patient to apply missed doses as soon as possible unless almost time for next dose. Pain relief lasts only as long as capsaicin is used regularly.
  • Inform patient that transient burning may occur with application, especially if applied less than 3–4 times daily. Burning usually disappears after the first few days but may continue for 2–4 wks or longer. Burning is increased by heat, sweating, bathing in warm water, humidity and clothing. Burning usually decreases in frequency and intensity the longer capsaicin is used. Decreasing number of daily doses will not lessen burning but may decrease amount of pain relief and may prolong period of burning.
  • Caution patient to flush area with water if capsaicin gets into eyes and to wash with warm but not hot, soapy water if capsaicin gets on other sensitive areas of the body. A diluted vinegar solution can be used to remove capsicum cream (capsaicin is not water washable).
  • Instruct patients with herpes zoster (shingles) not to apply capsaicin cream until lesions have completely healed.
  • Advise patient to discontinue use and notify health care professional if pain persists longer than 1 mo, worsens, or if signs of infection occur.

Evaluation/Desired Outcomes

  • Decrease in discomfort associated with:.
    • postherpetic neuralgia.
    • disbetic neuropathy.
    • rheumatoid arthritis.
    • osteiarthritis.
  • Pain relief usually begins within 1–2 wks with arthritis, 2–4 wks with nauralgia, and 4–6 wks with neuralgias of the head and neck.
(1) A condiment used in certain cuisines, in particular Mexican, that is particular high in capsaicin
(2) Cayenne, see there, Capsicum frutescens
The intensity of the ‘sting’ of hot chillis is measured in Scoville units
References in periodicals archive ?
Capsaicin is the active component in chili which reportedly speeds up metabolism, fat loss and inhibits vascular disorders, but this is the first longitudinal study to investigate the association between chili intake and cognitive function, researchers said.
Epidemiologist Ming Li from the University of South Australia, who is a co-author of the study, explained that only fresh and dried chili peppers have been found harmful for the brain.
Sangachholing gewog AEO, Tshering Lhamo said that around 25 farmers earned around Nu 500,000 last year and this year the number of farmers who want to cultivate chili under the program has increased to 41.
Ed Currie created the "Carolina Reaper" -- however, his intentions were not to create the world's spiciest chili. He became interested in growing chilis after learning that capsaicin could be used as a drug to combat cancer.
The total revenue from the sale of chili peppers in the world is expected to exceed $30 billion in 2017.
Round out your chili meal with a veggie-rich salad and whole grains, such as whole grain crackers, corn bread, whole wheat pasta or brown rice.
Chili peppers bright red color signals its high content of beta-carotene or pro-vitamin A.
The People's Choice Award, voted best tasting chili by those who attended the event, went to CHOC Full o' Chili from the $11.4 billion SchoolsFirst FCU in Santa Ana, Calif.
So the next time you have that last cup of leftover chili, don't relegate it to a light lunch at the office.
Tasting kits will be available for purchase—this kit is the only opportunity to taste chili and cast a vote for the People's Choice Chili, amateur and restaurant cook offs as well as a way to support a favorite service organization/nonprofit.
This year the promoters of the yearly chili cookoff included a category for charities.
The best chili con carne is made with a lot of well flavored mild or medium hot chillies not one searingly hot one.