To address this question, Lenschow and colleagues developed a reporter system to permanently mark cells infected by chikungunya
Taiwan reported in July the first indigenous case of chikungunya
fever in the country's history and samples of the chikungunya
virus were found to contain sequences of the gene identical to those of the virus strain from Myanmar this year, according to the CDC.
Most of these cases were brought in from countries in Southeast Asia, and more than half were from Myanmar, the CDC said, adding that the genome sequence of the chikungunya
virus strain found in the single indigenous case was similar to the cases from Myanmar.
Valneva will also maintain a stockpile of the vaccine candidate and work to transfer the secondary manufacturing of the drug product to partners for lower and middle income countries-where outbreaks of Chikungunya
have occurred-to improve access to the vaccine for at-risk populations.
At the moment, dengue cases are on the decline, but we are quite worried about the occurrence of chikungunya
Following an outbreak of Chikungunya
in Karachi in 2017 and subsequently detection of travel associated cases in different parts of the country, the disease is now endemic in many parts of the country like dengue fever.
Studies have shown that VLP vaccines are highly immunogenic, have a proven safety record, and typically elicit high titer neutralizing antibodies needed to protect against chikungunya
Co-infection of Dengue with Chikungunya
was seen in 8(9.1%) patients.
The term chikungunya
is derived from a Kimakonde (central Bantu) word meaning "that which bends up" because of the arthralgia caused by the disease.
The sequence analysis of the E1 gene using the Dengue, Zika & Chikungunya
Virus Typing Tool revealed that the sequences from Puerto Rico belong to the Asian genotype, Caribbean clade (data not shown).
Thereafter, sporadic cases of chikungunya
have been reported (7); however, in 2017, chikungunya
emerged as an important public health issue (8).
has an incubation period of two to 12 days with more than 70% of infected individuals becoming symptomatic.