cherubism


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cherubism

 [cher´oo͡-bizm]
hereditary and progressive bilateral swelling at the angle of the mandible, sometimes involving the entire jaw, imparting a cherubic look to the face, in some cases enhanced by upturning of the eyes.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

che·rub·ism

(cher'ŭb-izm), [MIM*118400]
Hereditary giant cell lesions of the jaws beginning in early childhood; multilocular radiolucencies and progressive symmetric painless swelling of the jaws; bilateral; occurs with no associated systemic manifestations.
[Hebr. kerubh, cherub]
Farlex Partner Medical Dictionary © Farlex 2012
An autosomal dominant [MIM 118400] condition, with 100% penetration in males who have a cherub-like physiognomy, that may be first recognised by age 5, when a child is obviously not losing the ‘baby fat’ in the face
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

cherubism

Familial intraosseous fibrous swelling of jaws An AD condition, 100% penetration in ♂ with a cherub-like physiognomy, first recognized by age 5 Clinical Puffed-out cheeks, agenesis of permanent teeth, dental dysgenesis, exophthalmos, progressive, bilateral soap-bubble expansile lesions of bone, at the mandibular angle, submandibular lymphadenopathy
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

che·rub·ism

(cher'ŭb-izm)
Progressive symmetric, painless swelling of the jaws beginning in early childhood due to hereditary giant cell lesions manifested radiographically as multilocular radiolucencies. Condition tends to regress during adulthood.
[Hebr. kerubh, cherub]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Jones,

William A., U.S. dentist.
Jones disease - genetic trait resulting in fullness of the face, suggestive of a cherub. Synonym(s): cherubism; Jones syndrome
Jones syndrome - Synonym(s): Jones disease
Medical Eponyms © Farlex 2012

che·rub·ism

(cher'ŭb-izm) [MIM*118400]
Hereditary giant cell lesions of the jaws beginning in early childhood involving swelling.
Synonym(s): fibrous dysplasia of jaws.
[Hebr. kerubh, cherub]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Ramon and Engelberg described a grading system for cherubism according to the lesion extension [14] as follows:
Grade 4: massive involvement of whole maxilla and mandible, except the condylar processes with involvement of the floor of the orbits causing orbital compression; according to this grading system, our patient belonged to grade 2 cherubism in which the lesion involved both mandibular ascending rami and maxillary tuberosities
Giant cell granuloma, hyperparathyroidism, Noonan's syndrome, Ramon syndrome, fibrous dysplasia, Jaffe-Campanacci syndrome, Neurofibromatosis type 1, and multiple odontogenic keratocysts are considered in differential diagnosis of cherubism. However, bilateral symmetry and posterior epicenter of cherubism can help to differentiate them.
Most of the cherubism cases show familial history, but there are some cases without familial histories of disorder [16,17].
Some literature has suggested Calcitonin therapy as an antiresorptive agent to reduce the cystic lesions of cherubism like central giant cell granuloma, but this treatment is not preferred in the rapidly growing lesions [17,20].
Svirsky, "Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors," Oral Surgery, Oral Medicine, Oral Pathology, vol.
Vinals, "Cherubism: a study of three generations," Medicina Oral, vol.
Ketcham, "Cherubism: an analysis of treatment," Cancer, vol.
`I could have plastic surgery to dramatically reduce the size of my chin but I've been told it could make my bottom lip go completely numb and may even aggravate the cherubism. It's not just because of the side effects I've decided against it, but on principle.
`I've just finished a degree in animation, media and society and my next challenge is setting up a support group to put people with cherubism and their doctors in touch with each other.
Cherubism. Cherubism is a rare, benign, autosomaldominant inherited condition characterized by cystic proliferation of the mandible and maxilla in childhood.
An extreme case of cherubism. Br J Oral Maxillofac Surg 2002;40:45-8.