chenodeoxycholic acid


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chenodeoxycholic acid

 [ke″no-de-ok″se-ko´lic]
one of the primary bile acids in humans, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion. The pharmaceutical preparation, called chenodiol, is used in treatment of gallstones.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id),
A major bile acid in many vertebrates, usually conjugated with glycine or taurine; it facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
Synonym(s): chenodiol

chenodeoxycholic acid

A bile acid with detergent properties. It has been used as a drug to dissolve GALLSTONES, but this takes 6 months to 2 years.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id)
A major bile acid in many vertebrates; facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
References in periodicals archive ?
Hu, "Extraction technique of chenodeoxycholic acid from duck bile paste," Journal of Tianjin University of Science & Technology, vol.
Qin, "Synthetic chenodeoxycholic acid derivative, HS-1200, induces apoptosis of human hepatoma cells via a mitochondrial pathway," Cancer Letters, vol.
The 4 major bile acids, lithocolic acid, cholic acid, deoxycholic acid and chenodeoxycholic acid (all supplied by Sigma Aldrich, SA) were selected for study.
Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: A randomized multicenter trial.
Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.
The ratio of cholic acid to chenodeoxycholic acid has been reported to be significantly higher in ICP pregnancies than in normal pregnancies (4 to 1 vs.
Treatment with chenodeoxycholic acid can be lifesaving.
TREATMENT with drugs such as chenodeoxycholic acid or urodeoxycholic acid can slowly dissolve the stones, but may cause side effects such as diarrhoea.
Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study.
Besides these changes, it has been shown that an increase of cereal fiber in the diet increases the production of chenodeoxycholic acid, which helps keep bile cholesterol in solution.