chenodeoxycholic acid


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chenodeoxycholic acid

 [ke″no-de-ok″se-ko´lic]
one of the primary bile acids in humans, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion. The pharmaceutical preparation, called chenodiol, is used in treatment of gallstones.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id),
A major bile acid in many vertebrates, usually conjugated with glycine or taurine; it facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
Synonym(s): chenodiol

chenodeoxycholic acid

A bile acid with detergent properties. It has been used as a drug to dissolve GALLSTONES, but this takes 6 months to 2 years.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id)
A major bile acid in many vertebrates; facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
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References in periodicals archive ?
Hu, "Extraction technique of chenodeoxycholic acid from duck bile paste," Journal of Tianjin University of Science & Technology, vol.
Study on the Factors Influencing the Extraction of Chenodeoxycholic Acid from Duck Bile Paste by Calcium Salt Method
Qin, "Synthetic chenodeoxycholic acid derivative, HS-1200, induces apoptosis of human hepatoma cells via a mitochondrial pathway," Cancer Letters, vol.
Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1
Treatment options include liver transplantation (4, 5) or preferably oral bile acid therapy with the primary bile acids, cholic or chenodeoxycholic acids (1, 6-12).
Tandem mass spectrometric determination of atypical 3[beta]-hydroxy-[[DELTA].sup.5]-bile acids in patients with 3[beta]-hydroxy-[[DELTA].sup.5]-[C.sub.27]-steroid oxidoreductase deficiency: application to diagnosis and monitoring of bile acid therapeutic response
Effect of Chenodeoxycholic Acid on the Dyes Adsorption.
Equilibrium and kinetic aspects in the sensitization of monolayer transparent Ti[O.sub.2] thin films with porphyrin dyes for DSSC applications
The 4 major bile acids, lithocolic acid, cholic acid, deoxycholic acid and chenodeoxycholic acid (all supplied by Sigma Aldrich, SA) were selected for study.
The effect of physiological concentrations of bile acids on the in vitro growth of Mycobacterium tuberculosis
Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: A randomized multicenter trial.
Oral gallstone dissolution therapies
Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.
Organic anion transporter protein (OATP 1B1) encoded by SLCO1B1 gene polymorphism (388A>G) & susceptibility in gallstone disease
The ratio of cholic acid to chenodeoxycholic acid has been reported to be significantly higher in ICP pregnancies than in normal pregnancies (4 to 1 vs.
Pregnancy can alter liver function
Treatment with chenodeoxycholic acid can be lifesaving.
Derm Dx
TREATMENT with drugs such as chenodeoxycholic acid or urodeoxycholic acid can slowly dissolve the stones, but may cause side effects such as diarrhoea.
Dr Miriam Stoppard's Health Focus: When a fry-up is agony: Gallstones
Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study.
Hepatic and renal toxicity among patients ingesting sheep bile as an unconventional remedy for diabetes mellitus - Saudi Arabia, 1995
Besides these changes, it has been shown that an increase of cereal fiber in the diet increases the production of chenodeoxycholic acid, which helps keep bile cholesterol in solution.
Dr. Denis Burkitt: a passion for preventing disease

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