chemotherapeutics


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Related to chemotherapeutics: antitumor, chemotherapist

che·mo·ther·a·peu·tics

(kē'mō-thār-ă-pyū'tiks),
The branch of therapeutics concerned with chemotherapy.

chemotherapy

Medical history
A near-extinct synonym for antibiotic or anti-tuberculosis therapy.
 
Oncology
The use of various agents, most of which are toxic to dividing cells, to induce tumour cell lysis; successful chemotherapy (CT) is a function of tumour responsiveness, which most predictably occurs in lymphoproliferative malignancy (e.g., leukaemia and lymphoma) and small cell (undifferentiated) carcinoma. Because CT is most effective against rapidly proliferating cells, collateral damage to dividing cells in skin and hair, bone marrow and the GI tract is common, resulting in reversible hair loss, myelosuppression, and nausea and vomiting. A late effect of CT, especially in paediatric leukaemia, is induction of a 2nd malignancy, which may be refractory to therapy.
References in periodicals archive ?
Collateral angiography can be performed at the diaphragmatic artery, intercostal artery, adrenal artery, or the thoracic artery, besides the routine celiac artery and superior mesenteric arteries, if necessary, and super-selective embolization can be achieved.[14],[15] Chemotherapeutics targeting different phases of the cell cycle are recommended, and combined use of chemotherapeutics is preferred.
The liver, also known as the major detoxifying organ in the body, has a crucial part in transforming and clearing chemicals from systemic circulation, which makes it vulnerable to the toxicity caused by chemotherapeutic agents.
Chemotherapeutics have been used with some success in birds.
Regarding potential health effects of redox modulators on tumours, they are mainly attributed to cancer chemoprevention, direct anticancer action (for comprehensive review, see [23]), cancer sensitisation to conventional chemotherapeutics, preferentially through MDR suppression/reversal, cancer sensitisation to radio- and photodynamic therapies, and protection of normal host organs/tissues against damage by chemo- and radiotherapy (Figure 2).
The company introduced its PDC platform for the targeted delivery of chemotherapeutics during its second quarter financial results call in August 2015.
The researchers discovered that several chemotherapeutics that stop fast growing tumors have the opposite effect on stem cells in the same animal, causing them to divide too rapidly.
Locally Applied Chemotherapeutics. For implant patients especially those prone to occasional tissue inflammation, an at-home regimen of daily cleansing with chemotherapeutic agents in the form of rinses, gels, or solutions is extremely essential.
While several targeted chemotherapeutics have been developed, the use of these drugs is limited to those patients who exhibit the proper cellular profile, such as triple negative or HER2 positive [2-7].
After four decades they still remain among the most commonly prescribed chemotherapeutics. These include the taxanes (paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).
Recent studies indicated that genetic polymorphism in GSTP1 and GSTM1 genes play a role in the efficacy of detoxifying cytotoxins generated by chemotherapeutics, including cisplatin and platinum agents, such as adriamycin, methotrexate, cisplatin and vincristine.9-13 Our study indicated that GSTP1 Ile105Val polymorphism may influence the chemotherapy efficacy in patients with osteosarcoma, and individuals with GSTP1GG genotype had poor response to chemotherapy and a shorter survival time.
Objective: The expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein and its regulation by chemotherapeutics were analyzed in primary acute leukemic cells.
In the recent years many studies on anthocyanins have revealed their strong antioxidant activity and their possible use as chemotherapeutics. The finding that sour cherries (Prunus cerasus L) (also called tart cherries) contain high levels of anthocyanins that possess strong antioxidant and anti-inflammatory properties has attracted much attention to this species.