chemotherapeutic agent


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Related to chemotherapeutic agent: chemotherapy

chemotherapeutic agent

An agent used to treat cancer administered in regimens of one or more cycles, combining two or more agents over a period of days to weeks. Such agents are toxic to cells with high proliferative rates—e.g., to the cancer itself, but also to the GI tract (causing nausea and vomiting), bone marrow (causing various cytopenias) and hair (resulting in baldness).

Examples
Busulphan, cisplatin, cyclophosphamide, MTX, daunorubicin, doxorubicin, melphalan, vincristine, vinblastine, chlorambucil.

chemotherapeutic agent

An agent used to treat CA, administered in 'regimens'-one or more 'cycles' that combine 3 or more agents over wks; CAs are toxic to any cell with a high rate of proliferation–the CA itself, the GI tract–causing N&V, BM–cytopenias, and hair—alopecia Examples Busulphan, cisplatin, cyclophosphamide, MTX, daunorubicin, doxorubicin, melphalan, vincristine, vinblastine, chlorambucil. See Immunosuppressive agents.

che·mo·ther·a·peu·tic a·gent

(kēmō-thār-ă-pyūtik ājĕnt)
Chemical that is used for therapeutic reasons.
References in periodicals archive ?
These cells were then tested for sensitivity to various chemotherapeutic agents. Sensitivity in the antisense-treated cells improved markedly as GCS levels decreased.
Several chemotherapeutic agents are currently used to treat malignant brain tumors and may be given before, during, or after radiation therapy and then again at the time of tumor progression (Prados & Levin, 2000).
(4) P-gp proteins are pumps that actively extrude the "activated" chemotherapeutic agents from the interior of the cancer cells to the extracellular space where they can no longer exert their anti-tumor action (See Figure 2).
LOS ANGELES -- Chemotherapy during pregnancy may not lead to an elevated rate of fetal malformations if it is given after the first trimester, according to a report on the first 619 cases entered into the federal Registry of Pregnancies Exposed to Chemotherapeutic Agents.
The drug doxorubicin is a chemotherapeutic agent commonly used as treatment for a variety of cancers.
Arsenic compounds are also being used as cancer chemotherapeutic agents. In humans, inorganic arsenic is metabolically methylated to mono-, di-, and trimethylated forms.
A first-line chemotherapeutic agent for patients with metastatic colorectal cancer, in combination with 5-fluorouracil/leucovorin (5-FU/LV).
"We are finding that sarcophine-diol could be used both for chemoprevention and as a chemotherapeutic agent," said Dwivedi.
The toxicity of 5-fluorouracil is about average for a chemotherapeutic agent, he said.
During the randomised double-blind, placebo-controlled trial, the efficacy and safety of the product was evaluated in combination with capecitabine, an oral chemotherapeutic agent, compared to placebo plus capecitabine.
He obtains excellent relief for his patients from the side effects of chemotherapy by daily "neutralization" to the chemotherapeutic agent. If this result can be reproduced by others it should become a routine part of chemotherapy.
In February 1998, a report of such chemosensitization appeared in Nature Medicine, a peer-reviewed, scientific journal, G3139 was shown to enhance the effect of a standard chemotherapeutic agent, DTIC or dacarbazine, in a mouse model of human malignant melanoma.