Furthermore, they generate reactive oxygen species (ROS), antimicrobial peptides, serine proteases, and various cytokines and chemotaxins
, including interleukin- (IL-) 1[beta], IL-6, IL-10, and monocyte chemotactic protein-1 (MCP-1), which, in turn, modulate the inflammatory response and further attract monocytes and macrophages  (for a comprehensive review of neutrophil-derived cytokines, see ).
Finally, in addition to the principal role of chemokines in leukocyte migration in atherosclerosis, other molecules such as chemotaxins
may also play a role.
C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro.
Webster, "Human monocyte chemotaxis to complement-derived chemotaxins
is enhanced by Gc-globulin," Journal of Leukocyte Biology, vol.
Stone, "Carbon black nanoparticles induce type II epithelial cells to release chemotaxins
for alveolar macrophages," Particle and Fibre Toxicology, vol.
Transforming growth factor, along with other chemotaxins
, recruits key effector cells and the proteins they express and induces them to migrate to the edge of the wound.
Complement and other chemotaxins
become part of the reaction, and inflammation is amplified and perpetuated (Olsen & Stein, 2004).
Concurrent with histamine and serotonin, prostaglandins act as chemotaxins
to encourage neutrophil migration to the surgical incision site to commence phagocytosis.